Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Joslin researchers find key mechanism in increased atherosclerosis risk for people with diabetes

11.07.2013
Researchers at Joslin Diabetes Center have discovered that when excessive PKC beta is found in the endothelium, the thin layer of cells that line blood vessels, atherosclerosis is exacerbated. Their findings were published on-line on June 11 by Circulation Research.

For people with diabetes, the increased risk of cardiovascular disease is an unfortunate reality. This includes atherosclerosis, a condition where the walls of the artery thicken due to accumulating fatty deposits, which can lead to heart attack and stroke.

"Heart disease is a major cause of death for both type 1 and type 2 [diabetes]," says George King, M.D., Chief Scientific Officer and Director of Research at Joslin. A team of researchers at Joslin led by Dr. King is one step closer to finding a solution for this insidious problem.

It is known that diabetic episodes of hyperglycemia and elevated levels of fatty acids cause the body to produce excessive amounts of PKC beta, an enzyme that plays a number of biological roles and has been shown to affect the cardiovascular system.

To study the link between PKC beta and atherosclerosis, scientists compared two groups of mice that were bred without the ability to produce apoliprotein E, a lipoprotein that removes cholesterol and lipids from the blood stream, giving them an innate tendency to develop atherosclerosis. One of these two groups was also bred to produce excessive levels of PKC beta in the endothelium. Both groups were fed a high fat, Western diet for twelve weeks after which researchers assessed their cardiovascular health.

The mice all gained weight at the same rate and had comparable blood pressures, cholesterol, and triglyceride rates. However, the group of mice that had elevated PKC beta experienced drastically higher rates of atherosclerosis. Joslin researchers learned that PKC beta inhibits the body's natural anti-atherogenic responses, which normally prevent fatty deposits from building up in blood vessels. As a result, the amount of aortic plaque in the PKC beta mice was twice that of control mice and their aortic atherosclerotic lesions were 1.7 times larger. Their endothelial walls also displayed signs of increased infection and inflammation.

Researchers believe that this greater instance of cardiovascular disease occurs partly because PKC beta indirectly inhibits the production of the anti-atherogenic, nitric oxide. Nitric oxide is vital to cardiovascular health, reducing the work the heart has to perform to pump blood and lowering the heart rate. In fact, lowered levels of nitric oxide are an early indicator of cardiovascular disease.

Now that excessive PKC beta has been shown to exacerbate atherosclerosis, researchers are hopeful that they will find better ways to manage cardiovascular disease in diabetic patients.

"If we could come up with a treatment for decreasing PKC beta, it may decrease the risk of cardiovascular disease in both Type 1 and Type 2 diabetes," says Dr. King.

About Joslin Diabetes Center

Joslin Diabetes Center, located in Boston, Massachusetts, is the world's largest diabetes research and clinical care organization. Joslin is dedicated to ensuring that people with diabetes live long, healthy lives and offers real hope and progress toward diabetes prevention and a cure. Joslin is an independent, nonprofit institution affiliated with Harvard Medical School.

Our mission is to prevent, treat and cure diabetes. Our vision is a world free of diabetes and its complications. For more information, visit http://www.joslin.org.

About Joslin Research

Joslin Research comprises the most comprehensive and productive effort in diabetes research under one roof anywhere in the world. With 30-plus faculty-level investigators and an annual research budget of $36 million, Joslin researchers focus on unraveling the biological, biochemical and genetic processes that underlie the development of type 1 and type 2 diabetes and related complications.

Joslin research is highly innovative and imaginative, employing the newest tools in genetics, genomics and proteomics to identify abnormalities that may play a role in the development of diabetes and its complications. Joslin Clinic patients, and others with diabetes, have the option of participating in clinical trials at Joslin to help translate basic research into treatment innovations.

Joslin has one of the largest diabetes training programs in the world, educating 150 M.D. and Ph.D. researchers each year, many of whom go on to head diabetes initiatives at leading institutions all over the globe.

Jeffrey Bright | EurekAlert!
Further information:
http://www.joslinresearch.org

More articles from Health and Medicine:

nachricht Using fragment-based approaches to discover new antibiotics
21.06.2018 | SLAS (Society for Laboratory Automation and Screening)

nachricht Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>