Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Inhaled glucocorticoids during pregnancy and offspring pediatric diseases

16.12.2011
Inhaled glucocorticoids for the treatment of asthma during pregnancy are not associated with an increased risk of most diseases in offspring, but may be a risk factor for endocrine and metabolic disturbances, according to a new study.

In a population-based cohort study, 65,085 mother-child pairs from the Danish National Birth Cohort were followed up in real time from early pregnancy into childhood. "Maternal use of inhaled glucocorticoids for asthma during pregnancy was not related to an increased risk of most diseases in childhood, except for endocrine and metabolic disorders, as compared to the risk in asthmatic mothers without glucocorticoid inhalation during pregnancy," said first author Marion Tegethoff, PhD, associate faculty member in clinical psychology and psychiatry at the University of Basel, Switzerland. "Our data are mostly reassuring and support the use of inhaled glucocorticoids during pregnancy."

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

Of 65,085 mother-child pairs with live singleton pregnancies, 61,002 had no asthma during pregnancy (93.7%) and 4083 (6.3%) had asthma during pregnancy. Median age at end of follow-up was 6.1 years (range: 3.6 to 8.9 years). In statistical analyses adjusted for baseline predictors of child health, use (versus no use) of inhaled glucocorticoids was associated with a significantly increased risk for the first diagnosis of endocrine and metabolic disorders (hazard ratio [HR], 1.84; 95% confidence interval [CI], 1.13-2.99), but not of diseases in any other category. Results were similar when analyses were restricted to mother-child pairs exposed only to budesonide, the inhaled glucocorticoid used by the majority of women (79.9%) in the study.

"This is the first comprehensive study of potential effects of glucocorticoid inhalation during pregnancy on the health of offspring, covering a wide spectrum of pediatric diseases," said last author Gunther Meinlschmidt, PhD, associate faculty member in clinical psychology and epidemiology at the University of Basel, Switzerland. "While our results support the use of these widely used asthma treatments during pregnancy, their effect on endocrine and metabolic disturbances during childhood merits further study."

There were some limitations to the study, including a lack of data on daily inhalation doses, use of self-report of maternal asthma and the study's focus on glucocorticoid inhalation rather than other active ingredients or glucocorticoids administered by other routes.

"Our data have both clinical and public health implications," the authors concluded, "given that asthma is common in pregnant women and inhaled glucocorticoids are the recommended treatment."

About the American Journal of Respiratory Research and Critical Care Medicine:

With an impact factor of 10.191, the AJRRCM is a peer-reviewed journal published by the American Thoracic Society. It aims to publish the most innovative science and the highest quality reviews, practice guidelines and statements in the pulmonary, critical care and sleep-related fields.

Founded in 1905, the American Thoracic Society is the world's leading medical association dedicated to advancing pulmonary, critical care and sleep medicine. The Society's 15,000 members prevent and fight respiratory disease around the globe through research, education, patient care and advocacy.

Nathaniel Dunford | EurekAlert!
Further information:
http://www.thoracic.org

More articles from Health and Medicine:

nachricht Using fragment-based approaches to discover new antibiotics
21.06.2018 | SLAS (Society for Laboratory Automation and Screening)

nachricht Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>