Increased intake of fish can boost good cholesterol levels

People who increased their intake of fish to a minimum of 3–4 weekly meals had more large HDL particles in their blood than people who are less frequent eaters of fish. Large HDL particles are believed to protect against cardiovascular diseases. The results were published in PLOS ONE.

The consumption of fish has long been know to be beneficial for health; however, the mechanisms by which fats and other useful nutrients found in fish work in the human body are not fully known. This new study carried out at the UEF provides new information on how the consumption of fish affects the size and lipid concentrations of lipoproteins which transport lipids in the blood. The study participants increased their intake of fatty fish in particular.

It was observed that a higher intake of fish increased the number of large HDL particles and lipids contained in them. Population-based studies have shown that HDL cholesterol – also known as good cholesterol – and large HDL particles are efficient in sweeping extra cholesterol off artery walls. Large HDL particles have been associated with reduced risk of cardiovascular diseases, whereas small HDL particles may even have opposite effects.

Positive changes in lipid metabolism were observed in persons who increased their intake of fish most, i.e. in persons who ate at least 3–4 fish meals per week. The study participants ate fatty fish such as salmon, rainbow trout, herring and vendace. No added butter or cream was used in the preparation of fish. The study doesn't give answers to whether a similar effect would have been observed had the study participants mainly eaten low-fat fish such as zander and perch. Low-fat fish may have other health benefits such as lowering of blood pressure, which was observed in an earlier study carried out at the UEF.

State-of-the-art metabolomics was used in the study, enabling for instance a very detailed analysis of lipoprotein particles. The analyses were carried out by the university's NMR Metabolomics Laboratory. Traditionally, cholesterol is divided into “bad” LDL cholesterol and “good” HDL cholesterol, but this method allows the investigation of a total of 14 different particle classes. “People shouldn't fool themselves into thinking that if their standard lipid levels are OK, there's no need to think about the diet, as things are a lot more complicated than that. Soft vegetable fats and fish are something to prefer in any case,” Postdoctoral Researcher Maria Lankinen says.

However, the researchers emphasise that a dietary approach to the treatment of increased overall and LDL cholesterol levels is important.

The findings are well in line with the Finnish nutrition recommendations encouraging people to reduce the consumption of red meat and to increase the consumption of fish and other sea foods. Further information on the health effects of fish will become available in the near future as results from the Alfakala project carried out at the UEF Institute of Public Health and Clinical Nutrition become available. The study takes a more detailed approach into the health effects of fish- and plant-derived omega-3 fatty acids, and it studies the health effects of fatty and low-fat fish.

###

For further information, please contact:

Postdoctoral Researcher Maria Lankinen, email: maria.lankinen@uef.fi; tel: +358294454464

Lankinen M, Kolehmainen M, Jääskeläinen, Paananen J, Joukamo L, Kangas AJ, Soininen P, Poutanen K, Mykkänen H, Gylling H, Orešič M, Jauhiainen M, Ala-Korpela M, Uusitupa M, Schwab U. Effects of Whole Grain, Fish and Bilberries on Serum Metabolic Profile and Lipid Transfer Protein Activities – a Randomized Trial (Sysdimet). PLOS ONE 2014

Media Contact

Maria Lankinen EurekAlert!

All latest news from the category: Health and Medicine

This subject area encompasses research and studies in the field of human medicine.

Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine.

Back to home

Comments (0)

Write a comment

Newest articles

Lighting up the future

New multidisciplinary research from the University of St Andrews could lead to more efficient televisions, computer screens and lighting. Researchers at the Organic Semiconductor Centre in the School of Physics and…

Researchers crack sugarcane’s complex genetic code

Sweet success: Scientists created a highly accurate reference genome for one of the most important modern crops and found a rare example of how genes confer disease resistance in plants….

Evolution of the most powerful ocean current on Earth

The Antarctic Circumpolar Current plays an important part in global overturning circulation, the exchange of heat and CO2 between the ocean and atmosphere, and the stability of Antarctica’s ice sheets….

Partners & Sponsors