Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

IN-TIME shows equal benefit of home telemonitoring in ICD and CRT-D patients

19.05.2014

ICD patients and CRT-D patients benefit to an almost equivalent extent from home telemonitoring

Home telemonitoring is equally effective in ICD and CRT-D patients, a subanalysis of the IN-TIME trial has shown. The findings were presented for the first time today at the Heart Failure Congress 2014, held 17-20 May in Athens, Greece. The Congress is the main annual meeting of the Heart Failure Association of the European Society of Cardiology.

The prospective IN-TIME multicentre trial included 664 patients with chronic heart failure, class II or III New York Heart Association (NYHA) symptoms and left ventricular ejection fraction <35% who were receiving optimal medical therapy. Nearly two-thirds of patients (60%) received a cardiac resynchronisation defibrillator (CRT-D) while 40% received an implantable cardioverter defibrillator (ICD).

All of the implanted devices had a home telemonitoring capability. Patients were randomised in a 1:1 fashion to have the telemonitoring function switched on or off. For those patients who had the telemonitoring function switched on, data from their device was transmitted to a monitoring physician or clinic to enable early detection of arrhythmias or other complications. Patients with the telemonitoring switched off were followed up during visits to the clinic.

... more about:
»CRT-D »Cardiology »ICD »failure »mortality »receiving »risk »therapy

The findings of the overall study were presented at ESC Congress 2013. Briefly, the trial showed that telemonitoring reduced the proportion of patients with a worsened composite clinical score consisting of all cause mortality, overnight hospitalisation for worsened heart failure, change in NYHA class, and change in patient global self assessment from 27.2% to 18.9% (p=0.013) (primary outcome). Telemonitoring also reduced one-year mortality from 8.7% to 3.4% (p=0.004) (secondary outcome).

The current subanalysis of the IN-TIME trial, presented for the first time today, investigated whether home telemonitoring was equally effective in patients with a CRT-D and patients with an ICD.

Professor Gerhard Hindricks, principal investigator of the study, said: "We predefined this subanalysis because we wanted to know if our overall findings were the same in both device types. This would have an impact on the interpretation of the data and recommendations for treatment in these patient populations."

He continued: "The patient population receiving a CRT-D is quite different to the patient population receiving an ICD. Usually the patients with an indication for CRT implantation are at higher risk of worsening of heart failure during the natural course of the disease, and they profit more from defibrillator therapy with a cardiac resynchronisation function."

The researchers found that the relative risk of the primary outcome in the telemonitoring versus control group was similar in the ICD (0.61, p=0.06) and CRT-D (0.75, p=0.10) patients. The relative risk of the secondary outcome was also similar in both device groups (ICD: 0.38, p=0.15; CRT-D: 0.35, p=0.014).

Professor Hindricks said: "This subanalysis adds to the general finding of the IN-TIME trial. We now know that ICD patients and CRT-D patients benefit to an almost equivalent extent from home telemonitoring."

He concluded: "The take home message for clinicians is that if you have a patient with advanced heart failure and an ejection fraction less than 35% who is on optimal medical therapy, consider implantation of an ICD or CRT-D that is capable of home telemonitoring. Patients on both types of devices will benefit equally from home telemonitoring, with improved clinical outcomes including reduced mortality."

Jacqueline Partarrieu | Eurek Alert!
Further information:
http://www.escardio.org

Further reports about: CRT-D Cardiology ICD failure mortality receiving risk therapy

More articles from Health and Medicine:

nachricht Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>