Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Improving Tuberculosis Screening in Remote Areas

02.12.2019

Every year, 1.5 million people die from tuberculosis (TB) worldwide. Diagnosis and treatment is particularly difficult in remote rural areas. Today, the Swiss Tropical and Public Health Institute (Swiss TPH) together with international partners announce the launch of the 4-year TB TRIAGE+ project after signing a grant agreement with the European and Developing Countries Clinical Trials Partnership (EDCTP). TB TRIAGE+ will evaluate new diagnostic approaches to make active TB case finding more efficient and cost-effective in remote areas of southern Africa.

Tuberculosis (TB) is the number one infectious disease killer worldwide. Particularly in hard-to-reach populations, diagnosis and treatment of TB remains very challenging. In high-burden areas, one third of patients are never diagnosed.


Finding and testing tuberculosis patients in remote areas can be challenging.

Photo: Niklaus Labhardt/Swiss TPH

To find, diagnose and treat these patients, several countries have adopted active TB case finding campaigns. During such campaigns, people are asked about symptoms suggestive of TB and, if positive, will be tested with a molecular sputum test, the Xpert MTB/RIF.

“Testing everyone with Xpert MTB/RIF who presents with unspecific TB symptoms is labour intensive and costly, considering that the majority of people do not actually have TB,” said Klaus Reither, Head of the Clinical Research Unit at Swiss TPH and project leader of TB TRIAGE+.

“A much more efficient and cost-effective method would be to do a triage test first to exclude people who are very unlikely to have TB. The molecular test would then only need to be performed on those with a high probability.”

The TB TRIAGE+ project will assess the accuracy, impact and cost-effectiveness of novel active TB case finding strategies at a community level, which will help to triage potential TB patients. The centerpiece of TB TRIAGE+ is a large-scale cluster-randomized clinical trial in rural communities of Lesotho and KwaZulu-Natal in South Africa, which are areas heavily affected by both the TB and HIV epidemics. TB TRIAGE+ is funded by EDCTP with EUR 3.19 million and starts on 1 January 2020.

Novel x-ray analysis and blood marker to triage patients

“The aim of the main trial of TB TRIAGE+, which will includes 35,000 people, is to identify a suitable triage strategy which improves early access to diagnosis and treatment and will substantially reduce diagnostic costs,” said Reither.

On the one hand, the project will test the automated chest x-ray analysis platform (CAD4TB), which can tell within seconds whether there is evidence of pulmonary TB. “CAD4TB has become a high-throughput screening tool, meaning that many people can be screened for TB in a short period of time.

In combination with a portable x-ray machine, we will perform and analyse chest radiographs even in the most remote settings,” said Reither. On the other hand, the C-reactive protein test, a well-known blood marker for inflammation and infection, will be tested for its potential as a point-of-care TB triage test. In the trial, both approaches will be compared to the current standard of care.

About TB TRIAGE+

Apart from the large community trial, TB TRIAGE+ also intends to answer a range of research questions linked to triage testing and active TB case finding. The project will also build research capacity and new networks for future research.

Swiss TPH leads TB TRIAGE+ in partnership with SolidarMed (Lesotho/Switzerland), the Human Sciences Research Council (South Africa), the Institute of Tropical Medicine in Antwerp (Belgium), the Radboud University Medical Center, Nijmegen (Netherlands), the Charité Universitätsmedizin Berlin (Germany) and University Hospital of Basel (Switzerland).

Wissenschaftliche Ansprechpartner:

Klaus Reither, Head of the Clinical Research Unit at Swiss TPH and project leader of TB TRIAGE+, Tel. 061 284 89 67, klaus.reither@swisstph.ch

Weitere Informationen:

https://www.swisstph.ch/en/news/news-detail/news/improving-tuberculosis-screenin...

Sabina Beatrice-Matter | idw - Informationsdienst Wissenschaft
Further information:
https://www.swisstph.ch

Further reports about: C-reactive protein TB TuBerculosis blood marker x-ray analysis

More articles from Health and Medicine:

nachricht How do scars form? Fascia function as a repository of mobile scar tissue
28.11.2019 | Helmholtz Zentrum München - German Research Center for Environmental Health

nachricht Helper protein worsens diabetic eye disease
28.11.2019 | Johns Hopkins Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: How do scars form? Fascia function as a repository of mobile scar tissue

Abnormal scarring is a serious threat resulting in non-healing chronic wounds or fibrosis. Scars form when fibroblasts, a type of cell of connective tissue, reach wounded skin and deposit plugs of extracellular matrix. Until today, the question about the exact anatomical origin of these fibroblasts has not been answered. In order to find potential ways of influencing the scarring process, the team of Dr. Yuval Rinkevich, Group Leader for Regenerative Biology at the Institute of Lung Biology and Disease at Helmholtz Zentrum München, aimed to finally find an answer. As it was already known that all scars derive from a fibroblast lineage expressing the Engrailed-1 gene - a lineage not only present in skin, but also in fascia - the researchers intentionally tried to understand whether or not fascia might be the origin of fibroblasts.

Fibroblasts kit - ready to heal wounds

Im Focus: McMaster researcher warns plastic pollution in Great Lakes growing concern to ecosystem

Research from a leading international expert on the health of the Great Lakes suggests that the growing intensity and scale of pollution from plastics poses serious risks to human health and will continue to have profound consequences on the ecosystem.

In an article published this month in the Journal of Waste Resources and Recycling, Gail Krantzberg, a professor in the Booth School of Engineering Practice...

Im Focus: Machine learning microscope adapts lighting to improve diagnosis

Prototype microscope teaches itself the best illumination settings for diagnosing malaria

Engineers at Duke University have developed a microscope that adapts its lighting angles, colors and patterns while teaching itself the optimal...

Im Focus: Small particles, big effects: How graphene nanoparticles improve the resolution of microscopes

Conventional light microscopes cannot distinguish structures when they are separated by a distance smaller than, roughly, the wavelength of light. Superresolution microscopy, developed since the 1980s, lifts this limitation, using fluorescent moieties. Scientists at the Max Planck Institute for Polymer Research have now discovered that graphene nano-molecules can be used to improve this microscopy technique. These graphene nano-molecules offer a number of substantial advantages over the materials previously used, making superresolution microscopy even more versatile.

Microscopy is an important investigation method, in physics, biology, medicine, and many other sciences. However, it has one disadvantage: its resolution is...

Im Focus: Atoms don't like jumping rope

Nanooptical traps are a promising building block for quantum technologies. Austrian and German scientists have now removed an important obstacle to their practical use. They were able to show that a special form of mechanical vibration heats trapped particles in a very short time and knocks them out of the trap.

By controlling individual atoms, quantum properties can be investigated and made usable for technological applications. For about ten years, physicists have...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

First International Conference on Agrophotovoltaics in August 2020

15.11.2019 | Event News

Laser Symposium on Electromobility in Aachen: trends for the mobility revolution

15.11.2019 | Event News

High entropy alloys for hot turbines and tireless metal-forming presses

05.11.2019 | Event News

 
Latest News

Fight diabetes with exercise

02.12.2019 | Life Sciences

Improving Tuberculosis Screening in Remote Areas

02.12.2019 | Health and Medicine

Big Data makes intensive care better

02.12.2019 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>