For the very first time high altitude physicians from Eurac Research, working with an international team of experts, have drawn up a set of guidelines for research in high mountain regions.Study location, exact altitude and a detailed profile of the study participants are just three of altogether 42 factors which are to be included in any future study, project description or publication related to high altitude medicine. A select group of experts, including high altitude physicians from all over the world, were invited to define which factors were most pertinent for inclusion in the guidelines by forming a consensus through multiple rounds of discussion.
The aim of these guidelines is to standardise data capture in this area of research and thereby guarantee, and indeed improve the quality of clinical research. Scientists from Eurac Research led the evaluation and coordinated the group of experts.
“Up until now it was frequently the case that data was not collected in a consistent manner or that key data was missing from study reports. Consequently this made it very difficult for researchers to replicate studies or to make comparisons between studies. These new guidelines will provide scientists and physicians alike with a more structured approach, informing both their study design and publication content relating to high altitude research,” says Monika Brodmann Maeder, High Altitude Physician at Eurac Research.
The factors considered fundamental to high altitude research by the expert group range from information relating to prevailing local conditions, to the personal characteristics of the study participants. Thus, in line with the guidelines researchers should indicate the altitude of the starting point, maximum altitude reached, and the altitude where night camps are set up. Using these collective data, researchers will be able to establish specific altitude profiles and ascent rates, in a bid to better ascertain inter alia why high altitude diseases occur more frequently in one scenario rather than another.
Additionally, along with the age and gender of the study participants, information should be logged as to whether they should be considered altitude native or naïve. Equally, considered crucial was the medical history of each of the study participants, i.e. record of incidence and medical treatment received for serious high altitude pathologies such as: high altitude cerebral oedema, high altitude pulmonary oedema, and acute mountain sickness.
In future, scientists should also record data on whether study participants received additional oxygen and to what extent. The guidelines also contain a series of definitions which should ensure that researchers all over the world have a common understanding of each term commonly used to describe high altitude pathologies.
“Using these guidelines will standardise data collection and enable study results to be readily used and compared in this new era of open science. We expect this to increase the validity of research in high altitude medicine,” Monika Brodmann Maeder continues.
These new guidelines will play a significant role in shaping high altitude research protocols inside the heavily anticipated terraXcube climate simulator, due to open in Bolzano (Italy) in autumn 2018. Equally, these guidelines provide the necessary structure and emphasis to standardise data collection worldwide, enabling scientists to even compare data taken from field studies with those data obtained under simulated chamber conditions.
The guidelines are freely available from: http://online.liebertpub.com/doi/pdfplus/10.1089/ham.2017.0160
Sara Senoner | idw - Informationsdienst Wissenschaft
Study shows novel protein plays role in bacterial vaginosis
13.12.2019 | University of Arizona Health Sciences
Illinois team develops first of a kind in-vitro 3D neural tissue model
12.12.2019 | University of Illinois College of Engineering
Vaccinia viruses serve as a vaccine against human smallpox and as the basis of new cancer therapies. Two studies now provide fascinating insights into their unusual propagation strategy at the atomic level.
For viruses to multiply, they usually need the support of the cells they infect. In many cases, only in their host’s nucleus can they find the machines,...
More than one hundred and fifty years have passed since the publication of James Clerk Maxwell's "A Dynamical Theory of the Electromagnetic Field" (1865). What would our lives be without this publication?
It is difficult to imagine, as this treatise revolutionized our fundamental understanding of electric fields, magnetic fields, and light. The twenty original...
In a joint experimental and theoretical work performed at the Heidelberg Max Planck Institute for Nuclear Physics, an international team of physicists detected for the first time an orbital crossing in the highly charged ion Pr⁹⁺. Optical spectra were recorded employing an electron beam ion trap and analysed with the aid of atomic structure calculations. A proposed nHz-wide transition has been identified and its energy was determined with high precision. Theory predicts a very high sensitivity to new physics and extremely low susceptibility to external perturbations for this “clock line” making it a unique candidate for proposed precision studies.
Laser spectroscopy of neutral atoms and singly charged ions has reached astonishing precision by merit of a chain of technological advances during the past...
The ability to investigate the dynamics of single particle at the nano-scale and femtosecond level remained an unfathomed dream for years. It was not until the dawn of the 21st century that nanotechnology and femtoscience gradually merged together and the first ultrafast microscopy of individual quantum dots (QDs) and molecules was accomplished.
Ultrafast microscopy studies entirely rely on detecting nanoparticles or single molecules with luminescence techniques, which require efficient emitters to...
Graphene, a two-dimensional structure made of carbon, is a material with excellent mechanical, electronic and optical properties. However, it did not seem suitable for magnetic applications. Together with international partners, Empa researchers have now succeeded in synthesizing a unique nanographene predicted in the 1970s, which conclusively demonstrates that carbon in very specific forms has magnetic properties that could permit future spintronic applications. The results have just been published in the renowned journal Nature Nanotechnology.
Depending on the shape and orientation of their edges, graphene nanostructures (also known as nanographenes) can have very different properties – for example,...
03.12.2019 | Event News
15.11.2019 | Event News
15.11.2019 | Event News
13.12.2019 | Physics and Astronomy
13.12.2019 | Physics and Astronomy
13.12.2019 | Materials Sciences