As the deaths and suffering caused by antibiotic-resistant bacterial infections continue to rise around the world, the Infectious Diseases Society of America (IDSA) is urging a global commitment to develop 10 new antibiotics by 2020, known as the 10 x '20 initiative, to address this public health crisis and safeguard patients' health.
The plea for U.S. and global action comes in a statement—published in the April 15 issue of Clinical Infectious Diseases and available online this week—that outlines the dangers and recommends how to address what the World Health Organization (WHO) has identified as one of the three greatest threats to human health. The IDSA statement is available at www.journals.uchicago.edu/doi/full/10.1086/652237. Recent studies have shown there are few antibiotics in the development pipeline that would offer benefits over existing drugs. The existing drugs we do have available are in danger of becoming ineffective as bacteria increasingly develop resistance.
"Prior generations gave us the gift of antibiotics," said David Gilbert, MD, FIDSA, chair of IDSA's Antimicrobial Availability Task Force, which authored the IDSA statement. "Today, we have a moral obligation to ensure this global treasure is available for our children and future generations."
Solving the antibiotic pipeline problem will require the engagement of global political, scientific, medical, industry and policy leaders to determine the right combination of incentives necessary to drive innovation in this diminishing segment of the pharmaceutical market. The ultimate goal must be the creation of a sustainable research and development enterprise that can deliver new antibiotics on an on-going basis. Resistant organisms will continue to develop in perpetuity, so we must have a plan in place to replenish our arsenal of drugs into the foreseeable future.
"The lack of new antibiotics in the pipeline threatens to leave physicians around the world without the tools they need to effectively treat patients, which could change the practice of medicine as we know it," said IDSA President Richard Whitley, MD, FIDSA. "Advances that we now take for granted, such as surgery, cancer treatment, transplants, and the care of premature babies, could become impossible as our antibiotic options dwindle. If we can initiate a global commitment to achieve this 10 x '20 goal, we will take a giant step toward protecting and ensuring the health of patients worldwide."
Sadly, this commitment will come too late for many patients and families who have already suffered the effects of antibiotic-resistant infections, underscoring the need for quick action to prevent even more suffering. These patients include:
Bryce Smith, who at 14-months-old contracted MRSA pneumonia in 2005 and nearly died. Bryce spent many harrowing weeks in an intensive care unit as doctors struggled to save his life and his parents, Katie and Scott, waited in agony for their son to recover.
For more information on these and other stories about patient's and families' experiences, please see IDSA's website: www.idsociety.org/badbugsnodrugspatientstories.htm.
Antimicrobial resistance has been a primary concern of IDSA's for many years. In 2004, the Society released "Bad Bugs, No Drugs, As Antibiotic Discovery Stagnates, A Public Health Crisis Brews," a report describing the antibiotic resistance crisis and detailing the factors driving drug makers out of the antibiotics market. The report is available at: www.idsociety.org/badbugsnodrugs.html. The Society has also worked with lawmakers to draft the Strategies to Address Antimicrobial Resistance (STAAR) Act, which provides important solutions to contain the spread of antimicrobial-resistant bad bugs. More information about the STAAR Act is available at www.idsociety.org/STAARAct.htm.
The Infectious Diseases Society of America (IDSA) is an organization of physicians, scientists, and other health care professionals dedicated to promoting health through excellence in infectious diseases research, education, patient care, prevention, and public health. The Society, which has more than 9,000 members, was founded in 1963 and is based in Arlington, Va.
John Heys | EurekAlert!
Neutrons produce first direct 3D maps of water during cell membrane fusion
21.09.2018 | DOE/Oak Ridge National Laboratory
Narcolepsy, scientists unmask the culprit of an enigmatic disease
20.09.2018 | Universitätsspital Bern
The building blocks of matter in our universe were formed in the first 10 microseconds of its existence, according to the currently accepted scientific picture. After the Big Bang about 13.7 billion years ago, matter consisted mainly of quarks and gluons, two types of elementary particles whose interactions are governed by quantum chromodynamics (QCD), the theory of strong interaction. In the early universe, these particles moved (nearly) freely in a quark-gluon plasma.
This is a joint press release of University Muenster and Heidelberg as well as the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt.
Then, in a phase transition, they combined and formed hadrons, among them the building blocks of atomic nuclei, protons and neutrons. In the current issue of...
Thin-film solar cells made of crystalline silicon are inexpensive and achieve efficiencies of a good 14 percent. However, they could do even better if their shiny surfaces reflected less light. A team led by Prof. Christiane Becker from the Helmholtz-Zentrum Berlin (HZB) has now patented a sophisticated new solution to this problem.
"It is not enough simply to bring more light into the cell," says Christiane Becker. Such surface structures can even ultimately reduce the efficiency by...
A study in the journal Bulletin of Marine Science describes a new, blood-red species of octocoral found in Panama. The species in the genus Thesea was discovered in the threatened low-light reef environment on Hannibal Bank, 60 kilometers off mainland Pacific Panama, by researchers at the Smithsonian Tropical Research Institute in Panama (STRI) and the Centro de Investigación en Ciencias del Mar y Limnología (CIMAR) at the University of Costa Rica.
Scientists established the new species, Thesea dalioi, by comparing its physical traits, such as branch thickness and the bright red colony color, with the...
Scientists have succeeded in observing the first long-distance transfer of information in a magnetic group of materials known as antiferromagnets.
An international team of researchers has mapped Nemo's genome, providing the research community with an invaluable resource to decode the response of fish to...
21.09.2018 | Event News
03.09.2018 | Event News
27.08.2018 | Event News
21.09.2018 | Physics and Astronomy
21.09.2018 | Life Sciences
21.09.2018 | Event News