Scientists from ITMO University created a high-speed video capillaroscopy system that enables direct measurement of red blood cell velocity. Coupled with sophisticated software, the system can raise the bar on the accuracy of vascular condition assessment. Such a system can come in useful for monitoring how efficient certain therapies are. The results of the research were published in Optics and Lasers in Engineering.
Capillaroscopy systems are commonly used either to determine the shape and size of a single capillary or to examine some specific part of a capillary network. Geometric patterns that emerge from capillary structures, as well as blood cell velocity, can reflect the condition of the entire vascular system. Although blood cell velocity is among crucial diagnostic parameters, so far its direct and precise measurement was not an easy task.
In the study, researchers from ITMO University applied high speed video recording of red blood cells in the capillary to measure blood flow velocity. The system relies on the combination of optical equipment with specially designed data processing software.
A microscope coupled with a high speed video camera captures the image of capillaries. The frame sequence is then processed in order to restore the capillaries' shape and configuration as well as to determine the distance that blood cells cover per time unit. Besides being useful for diagnostics, such data may help to assess whether a certain therapy is efficient or not.
"In addition to shape and diameter of each capillary, we can determine how fast red blood cells flow through each capillary in observed capillary net," comments Igor Gurov, lead author and head of the Center For Computational Optics, Photonics and Imaging at ITMO University. "Although relatively simple, our device is capable of providing reliable data that can be extremely useful for disease patterns recognition. What is more, such a diagnostic procedure is absolutely painless, safe and comfortable for patients."
Retrieving blood flow velocity data is of paramount importance when it comes to such diseases as diabetes or coronary heart disease. "Flow velocity is a primary factor in estimating the condition of any tissue by its blood supply. For instance, in diabetes the circulation speed may alter even though blood vessels generally appear to be normal. Our main task now is to use the system to address socially significant diseases. In particular, the system can be an effective tool for studying what happens in blood vessels during coronary heart disease and how drugs affect blood flow recovery," explains one of the authors Nikita Margariants.
By and large, other methods of measuring blood flow velocity cannot provide highly accurate data and do not allow for long-term measurements. "There are alternative devices that can only give a rough average estimate of blood cell velocity," comments Mikhail Volkov, researcher at the Center For Computational Optics, Photonics and Imaging.
The authors emphasize that the development of image recording and processing facilities will significantly expand the capabilities of the new system. "As new video cameras, exchange buses and software appear, this method will become better and more accurate. Time is on our side," points out Mikhail Volkov.
"High-speed video capillaroscopy method for imaging and evaluation of moving red blood cells"
I. Gurov, M. Volkov, N. Margaryants et al.
Optics and Lasers in Engineering Sep. 19, 2017 http://www.
Dmitry Malkov | EurekAlert!
Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University
Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
16.11.2018 | Health and Medicine
16.11.2018 | Life Sciences
16.11.2018 | Life Sciences