Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

"Hidden" fragrance compound can cause contact allergy

27.05.2015

Linalyl acetate, a fragrance chemical that is one of the main constituents of the essential oil of lavender, is not on the list of allergenic compounds pursuant to the EU Cosmetics Directive. Thus, it does not need to be declared on cosmetic products sold within the EU. Recent studies at the University of Gothenburg have shown that linalyl acetate can cause allergic eczema.

In accordance with the EU Cosmetics Directive, makeup, ointments, shampoo, deodorants, toothpaste and other products must contain a declaration of ingredients in order for consumers to avoid the substances to which they are allergic.


A person tested for contact allergy

University of Gothenburg

Cause of contact allergy
Linalyl acetate, a fragrance chemical, is an exception—it is not listed in the Directive and does not have to appear in declarations of ingredients. The substance is mildly allergenic. New studies at Sahlgrenska Academy have found that it can react with oxygen in the air to form strongly allergenic hydroperoxides. Thus, linalyl acetate may be a common cause of contact allergy.

Allergic reactions
The study included 1,717 subjects who were being assessed for eczema related to contact allergy. Approximately 2% of them had allergic reactions to oxidized linalyl acetate.

"That may seem like a small percentage," says Lina Hagvall, a researcher at the University of Gothenburg. "But it is approximately the same result as for the fragrance compounds listed in the Cosmetics Directive."

Broad range of tests
The subjects who reacted to oxidized linalyl acetate were also exposed to other fragrance compounds that are part of routine testing these days. A total of 57% of them had no allergic reaction.

"The trials suggest that a broad range of tests is required to detect contact allergies to fragrance compounds," Dr. Hagvall says. "Current tests do not identify the majority of people who have contact allergy to oxidized linalyl acetate.”

Hard to avoid
Because the substance is not declared on cosmetic products, consumers have trouble avoiding it, which can turn allergic eczema into a more severe, long-term condition.

According to the researchers, the study findings should lead to inclusion of oxidized linalyl acetate among the fragrance compounds used for diagnosis of contact allergy. The substance should also appear in the declaration of ingredients for cosmetic products.

"Air-oxidized linalyl acetate – An emerging fragrance allergen?" has been published in Contact Dermatitis.

Link to article: http://onlinelibrary.wiley.com/doi/10.1111/cod.12350/pdf

FACTS ABOUT CONTACT ALLERGY
Contact allergy involves development of an immunological memory for chemicals in the environment. The allergy generally manifests as eczema in the area of contact with the foreign substance. The allergic reaction arises when the substance bonds with skin proteins and triggers an immune response. Long-term contact can cause chronic, difficult-to-treat eczema.

The most frequent source of contact allergy is exposure to fragrance compounds, metals and preservatives. The Cosmetics Directive lists 26 fragrance chemicals and 2 natural extracts that must appear in declarations of ingredients.

For additional information, feel free to contact:
Lina Hagvall, PhD, Researcher, Sahlgrenska Academy, University of Gothenburg
Office +46 31-342 13 38
lina.hagvall@gu.se

Weitere Informationen:

http://sahlgrenska.gu.se/english/research/news-article/-hidden--fragrance-compou...

Henrik Axlid | idw - Informationsdienst Wissenschaft

More articles from Health and Medicine:

nachricht Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: It’s All in the Mix: Jülich Researchers are Developing Fast-Charging Solid-State Batteries

There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.

The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Air pollution leads to cardiovascular diseases

21.08.2018 | Ecology, The Environment and Conservation

Researchers target protein that protects bacteria's DNA 'recipes'

21.08.2018 | Life Sciences

A paper battery powered by bacteria

21.08.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>