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Gastric bypass reduces blood pressure

07.09.2011
The kidneys play an important role in the regulation of blood pressure by adjusting the production of urine after eating or drinking.
This process begins already in the upper digestive tract, which could explain why gastric bypass surgery for obesity also markedly reduce blood pressure, reveals a thesis from the Sahlgrenska Academy at the University of Gothenburg.

The kidneys can quickly adjust the production of urine after consumption of food or drink, which is important so that the composition of bodily fluids and the blood does not vary too much.

“My research shows that this elimination of urine starts already when salt and water reach the upper part of the digestive tract,” says researcher Peter Hallersund from the Sahlgrenska Academy. “So there’s a link between this part of the body and renal elimination.”

The thesis includes a study of 1,750 patients who underwent one of two types of obesity operations – gastric bypass or gastric banding. The results show that the elimination of urine increases after gastric bypass surgery. This can be explained by the fact that food and drink no longer come into contact with the upper part of the digestive tract, thus breaking the link between this part of the digestive system and the kidneys.

“We saw a long-term reduction in blood pressure after gastric bypass surgery, which could also be directly linked to the increase in patient’s daily amount of urine after the operation,” says Hallersund. “The gastric bypass probably reduces blood pressure in the same way as diuretic blood pressure medication.”

After ten years the decreased blood pressure following a gastric bypass was not related to the reduced weight and was markedly larger than after gastric banding. Dr Hallersund believes that this could be important when deciding between surgical methods for people who are overweight and have high blood pressure.

“A more unexpected finding in this study was that consumption of salty food increased after gastric bypass surgery, even though blood pressure went down. We think that this is because the operation also bypasses a link between the upper digestive tract and the brain which is important for suppressing our appetite for salt.”

GASTRIC BYPASS
Bariatric surgery is carried out to help obese patients lose weight. Gastric bypass involves the disconnecting of the stomach and the first section of the small intestine from the food’s passage through the digestive system so that food goes directly from the oesophagus into the small intestine. The result is that digestion is not as effective and that the surgery significantly reduces appetite, partly through an increase in appetite-suppressing intestinal hormones. On average, 75% of the excess weight disappears, and in many patients the weight stays off. Gastric banding is a different type of operation to reduce food consumption in obese patients who have not managed to lose weight in other ways. A band is placed around the stomach to slow down the passage of food. The long-term results of gastric banding are, however, less certain and demand a greater control of food consumption to avoid return to the original weight.
For more information, please contact:
Peter Hallersund, MD, PhD, researcher at the Department of Gastrosurgical Research and Education, Institute of Clinical Sciences, Sahlgrenska Academy, mobile: +46 (0)737 190 833, e-mail: peter.hallersund@gastro.gu.se
Publication data
Authors: Hallersund P, Elfvin A, Helander HF, Fändriks L.
Title: The expression of renin-angiotensin system components in the human gastric mucosa. J Journal: Renin Angiotensin Aldosterone Syst. 2011 Mar 12;54-64. Epub 2010 Aug.

Helena Aaberg | idw
Further information:
http://hdl.handle.net/2077/25575
http://www.gu.se

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