The vaccines will be drinkable or given as a nasal spray. Professor Nils Lycke at MIVAC at the Sahlgrenska Academy will in cooperation with researchers at Chalmers University of Technology and Lund University, combine technologies to develop the next generation of effective mucosal vaccines based on immunomodulation and cell-targeted nanoparticles.
According to world-health organizations, vaccination programs against the most serious infectious diseases represent the single-most important measure to improve global health and prevent debilitating disease. However, as most vaccines are injected and given by highly-trained healthcare personnel they are more difficult to administer in many parts of the world and the use of syringes, which may be reused, increases the risk for blood born contamination and spread of infection.
Also traditional mass vaccination in case of pandemic spread of infection, as for example with influenza, is very costly and difficult to undertake with traditional vaccines.
Mucosal vaccines, drinkable or nasal spray vaccines, have many practical advantageous, but few mucosal vaccines are commercially available today. This is because mucosal vaccines need powerful adjuvants and finding effective formulations that protect the vaccine components from degradation in harsh mucosal environments, such as the gut intestine.
The adjuvant is the critical component of most vaccines that greatly enhances the immune response. For mucosal vaccines traditional adjuvants are not effective. Another advantage of mucosal vaccines is that the immune defense is located to the mucosal membranes that are the port of entry for most pathogens, including tuberculosis, influenza and HIV.
The research team has received funding from the Foundation to develop the next generation of effective mucosal vaccines based on their expertise in vaccine adjuvant and lipid nanoparticle research.
“We are now taking a unique and pioneering step towards a universal platform for mucosal vaccines by developing a new targeted lipid nanoparticle vaccine that combines knowledge from different disciplines,” says Nils Lycke.
The team of researchers to undertake the project are professors Nils Lycke and Mary-Jo Wick at the Sahlgrenska Academy, William Agace at Lund University, Fredrik Höök and Marta Bally at Chalmers.
The research group will take a conceptually new approach to combining effective adjuvants with lipid nanoparticles to direct these complexes to the dendritic cells in the mucosal membranes.
These cells are the key target for the next generation of mucosal vaccines and responsible for initiating vaccine immune responses. The researchers have complementing expertise to solve the problems of how to combine all the expected properties of the mucosal vaccine in one particle.
“Thanks to a flexible particle design, and extensive experience with a patented adjuvant system we hope to be successful in our efforts” says Nils Lycke. If successful, the next generation of mucosal vaccines will have a major impact not only on vaccine prevention of infections, but also on global health ” says Nils Lycke.
“The idea is unique in several respects. No one has previously combined these components in a particle and no one has, in a structured manner, optimized the lipid particles to make mucal inoculations effective.”
The research project brings together four internationally successful research leaders with expertise in immunology, nano-biotechnology and vaccine development.For further information, please contact:
Torsten Arpi | idw
The genes are not to blame
20.07.2018 | Technische Universität München
Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
20.07.2018 | Power and Electrical Engineering
20.07.2018 | Information Technology
20.07.2018 | Materials Sciences