One of the greatest risk factors for autoimmunity among women of childbearing age may be associated with exposure to mercury such as through seafood, a new University of Michigan study says.
The findings, which appear in Environmental Health Perspectives, found that mercury - even at low levels generally considered safe - was associated with autoimmunity. Autoimmune disorders, which cause the body's immune system to attack healthy cells by mistake, affects nearly 50 million Americans and predominately women.
Emily Somers is associate professor at the University of Michigan Medical and Public Health Schools.
Credit: U-M Health System
"We don't have a very good sense of why people develop autoimmune disorders," says lead author Emily Somers, Ph.D., Sc.M, an associate professor in the departments of Internal Medicine in the division of Rheumatology, Environmental Health Sciences, and Obstetrics & Gynecology at the U-M Medical and Public Health Schools.
"A large number of cases are not explained by genetics, so we believe studying environmental factors will help us understand why autoimmunity happens and how we may be able to intervene to improve health outcomes. In our study, exposure to mercury stood out as the main risk factor for autoimmunity."
Autoimmune disease - which can include such conditions as inflammatory bowel disease, lupus, Sjögren's syndrome, rheumatoid arthritis and multiple sclerosis - is among the 10 leading causes of death among women.
Researchers analyzed data among women ages 16-49 from the National Health and Nutrition Examination Survey from 1999-2004. Greater exposure to mercury was associated with a higher rate of autoantibodies, a precursor to autoimmune disease. Most autoimmune diseases are characterized by autoantibodies, proteins made by a person's immune system when it fails to distinguish between its own tissues and potentially harmful cells.
Many fish consumption recommendations are aimed at pregnant women, those who may become pregnant, nursing moms and young children. The Food and Drug Administration (FDA) and the Environmental Protection Agency (EPA) say pregnant women can safely eat up to 12 ounces (340 grams) of seafood a week. Fish such as swordfish, king mackerel and tilefish contain the highest levels of mercury while shrimp, canned light tuna and salmon have lower levels.
Authors note there are many health benefits to seafood, a lean protein packed with vital nutrients. However, the findings provide further evidence that women of reproductive age should be mindful of the type of fish they're eating."
"The presence of autoantibodies doesn't necessarily mean they will lead to an autoimmune disease," Somers said. "However, we know that autoantibodies are significant predictors of future autoimmune disease, and may predate the symptoms and diagnosis of an autoimmune disease by years.
"For women of childbearing age, who are at particular risk of developing this type of disease, it may be especially important to keep track of seafood consumption."
Additional Authors: Martha A Ganser, Jeffrey S Warren, Niladri Basu, Lu Wang, Suzanna M. Zick and Sung Kyun Park, all of U-M. Basu is also with the Faculty of Agricultural and Environmental Sciences at McGill University in Montreal, Quebec, Canada.
Funding: This work was supported by the National Institutes of Health, National Institute of Environmental Health Sciences (K01ES019909 and P30ES017885); and the NIH National Center for Research Resources (UL1RR024986)
Reference: "Mercury Exposure and Antinuclear Antibodies among Females of Reproductive Age in the United States," Environmental Health Perspectives, Feb.10, 2015.
Beata Mostafavi | EurekAlert!
Nitric oxide-scavenging hydrogel developed for rheumatoid arthritis treatment
06.06.2019 | Pohang University of Science & Technology (POSTECH)
Infants later diagnosed with autism follow adults’ gaze, but seldom initiate joint attention
24.05.2019 | Schwedischer Forschungsrat - The Swedish Research Council
The well-known representation of chemical elements is just one example of how objects can be arranged and classified
The periodic table of elements that most chemistry books depict is only one special case. This tabular overview of the chemical elements, which goes back to...
Light can be used not only to measure materials’ properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.
Ferroelectricity is a state in which the constituent lattice “looks” in one specific direction, forming a macroscopic electrical polarisation. The ability to...
Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.
The Earth’s gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...
Discovery by Brazilian and US researchers could change the classification of two species, which appear more akin to jellyfish than was thought.
The tube anemone Isarachnanthus nocturnus is only 15 cm long but has the largest mitochondrial genome of any animal sequenced to date, with 80,923 base pairs....
Researchers at Chalmers University of Technology, Sweden, have discovered a completely new way of capturing, amplifying and linking light to matter at the nanolevel. Using a tiny box, built from stacked atomically thin material, they have succeeded in creating a type of feedback loop in which light and matter become one. The discovery, which was recently published in Nature Nanotechnology, opens up new possibilities in the world of nanophotonics.
Photonics is concerned with various means of using light. Fibre-optic communication is an example of photonics, as is the technology behind photodetectors and...
29.04.2019 | Event News
17.04.2019 | Event News
15.04.2019 | Event News
18.06.2019 | Life Sciences
18.06.2019 | Life Sciences
18.06.2019 | Life Sciences