Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

No evidence for the routine use of aspirin in people with asymptomatic vascular events

01.09.2009
The routine use of aspirin for the primary prevention of vascular events in people with asymptomatic disease cannot be supported, according to results from the Aspirin for Asymptomatic Atherosclerosis (AAA) study.

The study is the first placebo-controlled randomised trial designed to determine the effect of aspirin in asymptomatic atherosclerosis as reflected by a low ankle brachial index (ABI). Results found no statistically significant difference in primary endpoint events between those subjects allocated to aspirin or placebo (HR 1•03, 95% CI 0•84-1•27).

Joint first author Professor Gerry Fowkes from the Wolfson Unit for Prevention of Peripheral Vascular Diseases in Edinburgh said: "It is possible that in the general population, aspirin could produce a smaller reduction in vascular events than this trial was designed to detect, but it is questionable whether such an effect, together with aspirin related morbidity, would justify the additional resources and health care requirements of an ABI screening programme."

The benefits of antiplatelet therapy in the prevention of future cardio- and cerebrovascular events is well established in patients with a clinical history of arterial vascular disease (secondary prevention); however, evidence in primary prevention is limited, with studies suggesting that any benefit of aspirin must be weighed against the risk of bleeding. The aim of the AAA trial was to determine the effectiveness of aspirin in preventing events in people with asymptomatic atherosclerosis detected by ABI screening.

The study recruited 28,980 men and women aged 50 to 75 years who were free of clinically evident cardiovascular disease in central Scotland; all were given an ABI screening test. Those with a low ABI (3350 subjects, ≤0•95 ABI) were entered into the trial and randomised to once daily 100 mg aspirin or placebo. Participants were followed up for a mean of 8•2 years and outcomes ascertained by annual contact, general practitioner records, linkage to discharges from Scottish hospitals, and death notification. The primary endpoint was a composite of initial fatal or non-fatal coronary event or stroke, or revascularisation. There were two secondary endpoints: all initial vascular events defined as a composite of a primary endpoint event or angina, intermittent claudication or transient ischaemic attack; and all-cause mortality.

Results showed that 357 participants had a primary endpoint event (13•5 per 1000 person years, 95%CI 12•2-15•0), 181 in the aspirin group and 176 in the placebo group. A vascular event comprising the secondary endpoint occurred in 578 participants, but again no statistically significant difference was found between the aspirin and placebo groups (288 vs 290 events). All-cause mortality was similar in both groups (176 v 186 deaths). An initial event of major bleeding requiring admission to hospital occurred in 34 (2%) of subjects in the aspirin group and 20 (1•2%) in the placebo group.

Commenting on the results (and on the use of ABI as a screening method), Professor Fowkes said: "Although the AAA trial was not of screening per se, the results would suggest that using the ABI as a tool to screen individuals free of cardiovascular disease in the community is unlikely to be beneficial if aspirin is the intervention to be used in those found to be at higher risk. Other more potent antiplatelets might be considered, but only if increased effectiveness in avoiding ischaemic events is not matched by increased bleeding."

* The ankle brachial index (ABI) is the ratio of systolic pressure at the ankle to that in the arm, and is used in vascular practice to confirm diagnosis and assess the severity of peripheral atherosclerosis in the legs. Lower levels of the ABI are also associated with higher rates of concomitant coronary and cerebrovascular disease and with the presence of cardiovascular risk factors.

Jacquelline Partarrieu | EurekAlert!
Further information:
http://www.escardio.org

More articles from Health and Medicine:

nachricht Researchers image atomic structure of important immune regulator
11.12.2018 | Brigham and Women's Hospital

nachricht Potential seen for tailoring treatment for acute myeloid leukemia
10.12.2018 | University of Washington Health Sciences/UW Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

Im Focus: Researchers develop method to transfer entire 2D circuits to any smooth surface

What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.

Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...

Im Focus: Three components on one chip

Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.

Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...

Im Focus: Substitute for rare earth metal oxides

New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals

Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.

Im Focus: A bit of a stretch... material that thickens as it's pulled

Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.

Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

Expert Panel on the Future of HPC in Engineering

03.12.2018 | Event News

 
Latest News

Electronic evidence of non-Fermi liquid behaviors in an iron-based superconductor

11.12.2018 | Physics and Astronomy

Topological material switched off and on for the first time

11.12.2018 | Materials Sciences

NIST's antenna evaluation method could help boost 5G network capacity and cut costs

11.12.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>