Autistic children showed a reduction in short range connectivity indicating poor function of local brain networks, especially in the left hemisphere regions responsible for language. However these children had increased connectivity between regions that were further apart indicating a compensatory mechanism.
Autism is characterized by impaired communication, including language and social skills, and often includes rigidity of interests, or repetitive, ritualistic behavior. While MRI studies have reported differing results, EEG measurements of brain activity have been more consistent.
Researchers from Harvard Medical School compared EEG measurements of almost 1000 children with and without autism. Data was collected using 24 electrodes on the scalps of awake and alert subjects and results adjusted for events known to confound EEG results such as blinking, head movement or drowsiness.
Dr Frank Duffy and Dr Heidelise Als who performed this research at the Boston Children's Hospital explained, "EEG coherence is used to assess functional connectivity within the brain. Across all the age groups we tested, a set of 40 coherence measurements reliably and consistently distinguished between children with ASD and their controls."
The EEG results showed widespread differences in brain connectivity. Specifically short distance coherence (between adjacent electrodes) was reduced in the children with ASD, especially in the left frontal regions associated with language. Conversely long distance coherence was increased, suggesting a compensatory mechanism.
In addition to behavioral assessments, the use of EEG-based testing may help reliably diagnose autism in children, and may assist early detection in infants, allowing for more effective therapies and coping strategies.
Media ContactDr Hilary Glover
Article citation and URL available on request on the day of publication.
2. BMC Medicine is the flagship medical journal of the BMC series, publishing original research, commentaries and reviews that are either of significant interest to all areas of medicine and clinical practice, or provide key translational or clinical advances in a specific field.
1. BioMed Central (http://www.biomedcentral.com/) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector.
Hilary Glover | EurekAlert!
New method uses just a drop of blood to monitor lung cancer treatment
19.10.2018 | Osaka University
Photoactive bacteria bait may help in fight against MRSA infections
12.10.2018 | Purdue University
Scientists at the Max Planck Institute for Polymer Research (MPI-P) in Mainz (Germany) together with scientists from Dresden, Leipzig, Sofia (Bulgaria) and Madrid (Spain) have now developed and characterized a novel, metal-organic material which displays electrical properties mimicking those of highly crystalline silicon. The material which can easily be fabricated at room temperature could serve as a replacement for expensive conventional inorganic materials used in optoelectronics.
Silicon, a so called semiconductor, is currently widely employed for the development of components such as solar cells, LEDs or computer chips. High purity...
Augsburg chemists present a new technology for compressing, storing and transporting highly volatile gases in porous frameworks/New prospects for gas-powered vehicles
Storage of highly volatile gases has always been a major technological challenge, not least for use in the automotive sector, for, for example, methane or...
When we put water in a freezer, water molecules crystallize and form ice. This change from one phase of matter to another is called a phase transition. While this transition, and countless others that occur in nature, typically takes place at the same fixed conditions, such as the freezing point, one can ask how it can be influenced in a controlled way.
We are all familiar with such control of the freezing transition, as it is an essential ingredient in the art of making a sorbet or a slushy. To make a cold...
Thin organic layers provide machines and equipment with new functions. They enable, for example, tiny energy recuperators. In future, these will be installed...
Das Zusammenspiel aus Struktur und Dynamik bestimmt die Funktion von Proteinen, den molekularen Werkzeugen der Zelle. Durch Fortschritte in der...
17.10.2018 | Event News
16.10.2018 | Event News
02.10.2018 | Event News
22.10.2018 | Ecology, The Environment and Conservation
22.10.2018 | Physics and Astronomy
22.10.2018 | Medical Engineering