Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Do drug therapies raise risk of bladder cancer?

28.10.2009
Dartmouth studies glucorticoid side effects

In her most recent study of possible triggers of cancer among northern New England residents, Dartmouth epidemiologist Margaret R. Karagas, Ph.D., and her team identified an enhanced risk to the bladders of patients taking drugs that suppress the immune system.

The findings, from a population-based, case-control study in New Hampshire, appear in the September 2009 issue of the British Journal of Cancer, with Dartmouth Medical School student Karl Dietrich as first author, with DMS professors Alan R. Schned, M.D., and John A. Heaney, M.D., as co-authors, and with Karagas, a professor of community and family medicine at DMS, as principal investigator.

The report examines the long-term use of glucocorticoids by 786 bladder-cancer patients and by 1,083 control subjects. Doctors commonly prescribe a combination of cytotoxic drugs and glucocorticoids as immunosuppressive therapy to help recipients of transplants avoid rejection of their new organs, and patients with rheumatoid arthritis, asthma, and other conditions often take glucocorticoids. Previous research, in some of which Karagas participated, has shown associations between such drug therapies and higher risk of skin cancer and lymphoma. A similar risk for bladder cancer, the new report says, "might indicate the need for closer monitoring of individuals who regularly take glucocorticoids."

In addition to teaching epidemiology, Karagas is section head of biostatistics and epidemiology at DMS, and co-director of the Norris Cotton Cancer Center's epidemiology and chemoprevention program. Schned is a professor of pathology and acting chair of that department at the medical school, where Heaney is a professor of surgery specializing in urology.

The journal article can be viewed here (http://www.nature.com/bjc/journal/v101/n8/full/6605314a.html)

David A. Corriveau | EurekAlert!
Further information:
http://www.dartmouth.edu
http://www.nature.com/bjc/journal/v101/n8/full/6605314a.html

More articles from Health and Medicine:

nachricht Neutrons produce first direct 3D maps of water during cell membrane fusion
21.09.2018 | DOE/Oak Ridge National Laboratory

nachricht Narcolepsy, scientists unmask the culprit of an enigmatic disease
20.09.2018 | Universitätsspital Bern

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists present new observations to understand the phase transition in quantum chromodynamics

The building blocks of matter in our universe were formed in the first 10 microseconds of its existence, according to the currently accepted scientific picture. After the Big Bang about 13.7 billion years ago, matter consisted mainly of quarks and gluons, two types of elementary particles whose interactions are governed by quantum chromodynamics (QCD), the theory of strong interaction. In the early universe, these particles moved (nearly) freely in a quark-gluon plasma.

This is a joint press release of University Muenster and Heidelberg as well as the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt.

Then, in a phase transition, they combined and formed hadrons, among them the building blocks of atomic nuclei, protons and neutrons. In the current issue of...

Im Focus: Patented nanostructure for solar cells: Rough optics, smooth surface

Thin-film solar cells made of crystalline silicon are inexpensive and achieve efficiencies of a good 14 percent. However, they could do even better if their shiny surfaces reflected less light. A team led by Prof. Christiane Becker from the Helmholtz-Zentrum Berlin (HZB) has now patented a sophisticated new solution to this problem.

"It is not enough simply to bring more light into the cell," says Christiane Becker. Such surface structures can even ultimately reduce the efficiency by...

Im Focus: New soft coral species discovered in Panama

A study in the journal Bulletin of Marine Science describes a new, blood-red species of octocoral found in Panama. The species in the genus Thesea was discovered in the threatened low-light reef environment on Hannibal Bank, 60 kilometers off mainland Pacific Panama, by researchers at the Smithsonian Tropical Research Institute in Panama (STRI) and the Centro de Investigación en Ciencias del Mar y Limnología (CIMAR) at the University of Costa Rica.

Scientists established the new species, Thesea dalioi, by comparing its physical traits, such as branch thickness and the bright red colony color, with the...

Im Focus: New devices based on rust could reduce excess heat in computers

Physicists explore long-distance information transmission in antiferromagnetic iron oxide

Scientists have succeeded in observing the first long-distance transfer of information in a magnetic group of materials known as antiferromagnets.

Im Focus: Finding Nemo's genes

An international team of researchers has mapped Nemo's genome

An international team of researchers has mapped Nemo's genome, providing the research community with an invaluable resource to decode the response of fish to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

"Boston calling": TU Berlin and the Weizenbaum Institute organize a conference in USA

21.09.2018 | Event News

One of the world’s most prominent strategic forums for global health held in Berlin in October 2018

03.09.2018 | Event News

4th Intelligent Materials - European Symposium on Intelligent Materials

27.08.2018 | Event News

 
Latest News

Astrophysicists measure precise rotation pattern of sun-like stars for the first time

21.09.2018 | Physics and Astronomy

Brought to light – chromobodies reveal changes in endogenous protein concentration in living cells

21.09.2018 | Life Sciences

"Boston calling": TU Berlin and the Weizenbaum Institute organize a conference in USA

21.09.2018 | Event News

VideoLinks
Science & Research
Overview of more VideoLinks >>>