Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Disrupting Sleep Causes Problems for the Body and Brain

28.10.2009
Anyone who has pulled an all-nighter or flown across an ocean knows you can’t mess up your sleep schedule without unpleasant consequences.

New research in mice now shows that throwing off natural circadian rhythms over the long term can seriously disturb the body and brain, causing weight gain and impulsive behavior. It seems even to make mice dumber, or at least slower at solving new mazes.

Rockefeller University postdoctoral fellow Ilia Karatsoreos, who led the research, says the implications for humans are significant. “In our modern, industrialized society, the disruption of our individual circadian rhythms has become commonplace, from shift-work and jet lag to the constant presence of electric lighting.

These disruptions are not only a nuisance, but can also lead to serious health and safety problems.” Karatsoreos, who works in Bruce S. McEwen’s Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, presented his findings October 19 in Chicago as part of a panel at Neuroscience 2009, the Society for Neuroscience’s annual meeting.

To test the neurological impact of disrupting circadian rhythms, Karatsoreos and colleagues adjusted the hours in which mice were exposed to light, from their natural 24-hour cycle to 20 hours, with 10 hours of light and 10 hours of dark. After six to eight weeks of these shortened days, these mice began acting differently than their peers in a control group. They also showed several physiological differences.

While not any more active than the control mice, the disrupted mice were impulsive, a behavior measured in part by how long they wait to emerge into the light from a dark compartment in a cage. They were slower to figure out changes made to a water maze they had mastered, suggesting reduced mental flexibility. Physically, their body temperature cycles were disorganized when compared to their peers and the levels of hormones related to metabolism, such as leptin, which regulates appetite, and insulin, were elevated. Consequently the mice gained weight even though they were fed the same diet as the controls.

The researchers also found that the brains of the disrupted mice had shrunken and less complex neurons in the medial prefrontal cortex, an area important to the so-called executive function, which regulates mental flexibility among other things. “Those changes may help explain some of the behavioral effects of circadian disruptions,” Karatsoreos says.

Brett Norman | Newswise Science News
Further information:
http://www.rockefeller.edu

More articles from Health and Medicine:

nachricht Neutrons produce first direct 3D maps of water during cell membrane fusion
21.09.2018 | DOE/Oak Ridge National Laboratory

nachricht Narcolepsy, scientists unmask the culprit of an enigmatic disease
20.09.2018 | Universitätsspital Bern

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists present new observations to understand the phase transition in quantum chromodynamics

The building blocks of matter in our universe were formed in the first 10 microseconds of its existence, according to the currently accepted scientific picture. After the Big Bang about 13.7 billion years ago, matter consisted mainly of quarks and gluons, two types of elementary particles whose interactions are governed by quantum chromodynamics (QCD), the theory of strong interaction. In the early universe, these particles moved (nearly) freely in a quark-gluon plasma.

This is a joint press release of University Muenster and Heidelberg as well as the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt.

Then, in a phase transition, they combined and formed hadrons, among them the building blocks of atomic nuclei, protons and neutrons. In the current issue of...

Im Focus: Patented nanostructure for solar cells: Rough optics, smooth surface

Thin-film solar cells made of crystalline silicon are inexpensive and achieve efficiencies of a good 14 percent. However, they could do even better if their shiny surfaces reflected less light. A team led by Prof. Christiane Becker from the Helmholtz-Zentrum Berlin (HZB) has now patented a sophisticated new solution to this problem.

"It is not enough simply to bring more light into the cell," says Christiane Becker. Such surface structures can even ultimately reduce the efficiency by...

Im Focus: New soft coral species discovered in Panama

A study in the journal Bulletin of Marine Science describes a new, blood-red species of octocoral found in Panama. The species in the genus Thesea was discovered in the threatened low-light reef environment on Hannibal Bank, 60 kilometers off mainland Pacific Panama, by researchers at the Smithsonian Tropical Research Institute in Panama (STRI) and the Centro de Investigación en Ciencias del Mar y Limnología (CIMAR) at the University of Costa Rica.

Scientists established the new species, Thesea dalioi, by comparing its physical traits, such as branch thickness and the bright red colony color, with the...

Im Focus: New devices based on rust could reduce excess heat in computers

Physicists explore long-distance information transmission in antiferromagnetic iron oxide

Scientists have succeeded in observing the first long-distance transfer of information in a magnetic group of materials known as antiferromagnets.

Im Focus: Finding Nemo's genes

An international team of researchers has mapped Nemo's genome

An international team of researchers has mapped Nemo's genome, providing the research community with an invaluable resource to decode the response of fish to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

"Boston calling": TU Berlin and the Weizenbaum Institute organize a conference in USA

21.09.2018 | Event News

One of the world’s most prominent strategic forums for global health held in Berlin in October 2018

03.09.2018 | Event News

4th Intelligent Materials - European Symposium on Intelligent Materials

27.08.2018 | Event News

 
Latest News

Three NASA missions return first-light data

24.09.2018 | Physics and Astronomy

Brown researchers teach computers to see optical illusions

24.09.2018 | Information Technology

Astrophysicists measure precise rotation pattern of sun-like stars for the first time

21.09.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>