Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New discoveries linking gut bacteria with cholesterol metabolism give hope for the future

18.02.2013
Researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden, show that cholesterol metabolism is regulated by bacteria in the small intestine. These findings may be important for the development of new drugs for cardiovascular disease.

It is well established that cholesterol is the major risk factor for cardiovascular disease. Cholesterol – which is mainly synthesized in the body but also obtained from dietary sources – is converted to bile acids in the liver, which are then secreted into the intestine and either removed from the body or recycled back to the liver.

The influence of gut bacteria on human health and disease is a rapidly expanding research area. Fredrick Bäckhed’s research group is a leader in this field and is investigating how gut bacteria are linked to lifestyle diseases such as obesity, diabetes and cardiovascular disease.

In a study published in the prestigious journal Cell Metabolism, they show that gut bacteria reduce bile acid synthesis in the liver by signaling through a specific protein, known as the FXR receptor, in the small intestine.

‘Drugs that reduce cholesterol levels have, in recent years, greatly reduced deaths from cardiovascular disease. Our study is a step forward because we have shown how gut bacteria regulate the formation of bile acids from cholesterol’, says Sama Sayin, medical doctor and PhD student at the Sahlgrenska Academy, University of Gothenburg, and the study's first author.

The FXR receptor not only affects cholesterol metabolism but is also involved in the body's sugar and fat metabolism.

‘If future research can identify the specific bacteria that affect FXR signaling in the gut, this could lead to new ways to treat diabetes and cardiovascular disease’, says Fredrik Bäckhed, professor at the Sahlgrenska Academy, University of Gothenburg, who led the study.

The article ‘Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-betamuricholic acid, a naturally occurring FXR antagonist’ is published in Cell Metabolism on February 5. The study is a collaboration with researchers from VTT in Finland, the Karolinska Institute and AstraZeneca in Mölndal.

The Wallenberg Laboratory: http://www.wlab.gu.se/

Contact:
Fredrick Bäckhed, professor at the Sahlgrenska Academy, University of Gothenburg, and director of the Wallenberg Laboratory, University of Gothenburg
+ 46 (0) 31-342 7833
+ 46 (0) 70-2182355
fredrik.backhed@wlab.gu.se
Sama Sayin, PhD student at the Wallenberg Laboratory and Department of Molecular and Clinical Medicine, University of Gothenburg
+ 46 (0) 31-342 8672
+ 46 (0) 73-1541051
sama.sayin@wlab.gu.se

Annika Koldenius | idw
Further information:
http://www.gu.se
http://www.wlab.gu.se/

More articles from Health and Medicine:

nachricht The genes are not to blame
20.07.2018 | Technische Universität München

nachricht Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes

20.07.2018 | Power and Electrical Engineering

Reversing cause and effect is no trouble for quantum computers

20.07.2018 | Information Technology

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern

20.07.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>