“The majority of diabetics will over time develop severe or fatal complications, but 10–15 per cent never do. They are the ones we are interested in in the PROLONG study”, explains Valeriya Lyssenko, who along with Peter Nilsson, both from Lund University Diabetes Centre, in Sweden, leads the PROLONG study.
The risk of dying from cardiovascular disease is two to three times higher for diabetics than for non-diabetics. The small blood vessels are also damaged. After only ten years with diabetes, 70 per cent of patients will have some form of kidney damage that may progress to kidney failure. As many suffer from eye complications – some will develop severe visual impairment and two per cent will become blind.
“The blood vessels and other organs of the body become sugar coated and stiff. It is reminiscent of premature biological ageing”, says Peter Nilsson.Half of the veterans
Today there are approximately 12 000 people in Sweden who have had diabetes for more than 30 years; of these, 1 600 have had it for over 50 years.
“About half of these diabetic veterans do not have major complications. Two thirds of those who have had diabetes for more than 50 years have escaped complications. Clearly they are different and we want to find out what it is that protects them”, says Valeriya Lyssenko.Greatest risk passed after 30 years
The 30-year limit has been chosen because a person who has had diabetes for such a long time without developing complications is unlikely to do so later in life.Copying nature’s protective mechanisms
“If we can identify factors protecting these veterans from devastating complications, then it might be possible to develop drugs that can do the same thing”, says Valeriya Lyssenko.
“I have dreamt of performing a study like this for a long time”, adds Peter Nilsson.
PROLONG stands for PROtective genes in diabetes and LONGevity
Major diabetic complications include kidney disease (nephropathy), eye damage (retinopathy), heart attacks and stroke.For more information:
Megan Grindlay | idw
Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
Foods of the future
15.08.2018 | Georg-August-Universität Göttingen
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Physics and Astronomy
17.08.2018 | Information Technology
17.08.2018 | Life Sciences