A device used to prevent incontinence in women who undergo a common pelvic-floor surgery reduces symptoms but increases side effects in these patients. These findings were published in the latest issue of the New England Journal of Medicine.
Women in this study underwent surgery for pelvic organ prolapse. Prolapse occurs when the pelvic organs fall and cause the vaginal wall to protrude outside of the body. About 1 in 5 women will undergo this surgery in her lifetime. Those who undergo surgery for this disorder are at risk for urinary incontinence following the procedure. As a result, surgeons commonly add a midurethral sling at the time of surgery to prevent this disorder.
“One-quarter of women develop incontinence after prolapse surgery, so it is critical that we have an effective option to manage this issue,” said Kimberly Kenton, MD, MS, FACOG, FACS, study co-author and director of Female Pelvic Medicine and Reconstructive Surgery, Loyola University Health System (LUHS).
“Slings do come with risks though, so one approach might be to only treat patients who develop incontinence after surgery,” she said.
This study evaluated 322 women at three months and 12 months following surgery. Half of the women received a midurethral sling and the other half received sham incisions. At three months, the rate of urinary incontinence was 23.6 percent in the sling group and 49.4 percent in the sham group. At 12 months, urinary incontinence was present in 27.3 percent and 43 percent, respectively. However, the rates of side effects were higher in the sling group. These included bladder perforations (6.7 versus 0 percent), urinary-tract infections (31 versus 18.3 percent), major bleeding complications (3.1 versus 0 percent) and incomplete bladder emptying six weeks following surgery (3.7 versus 0 percent). There were no significant differences between groups in changes in overall health, other pelvic-floor symptoms, sexual function and pain.
“Slings continue to be a valuable option for certain women, but we should avoid using them with all patients undergoing a procedure for pelvic-organ prolapse,” Dr. Kenton said. “This research reinforces the importance of counseling women on the risks and benefits of prolapse surgery prior to the procedure.”
Based in the western suburbs of Chicago, Loyola University Health System is a quaternary care system with a 61-acre main medical center campus, the 36-acre Gottlieb Memorial Hospital campus and 28 primary and specialty care facilities in Cook, Will and DuPage counties. The medical center campus is conveniently located in Maywood, 13 miles west of the Chicago Loop and 8 miles east of Oak Brook, Ill. The heart of the medical center campus, Loyola University Hospital, is a 569-licensed-bed facility. It houses a Level 1 Trauma Center, a Burn Center and the Ronald McDonald® Children's Hospital of Loyola University Medical Center. Also on campus are the Cardinal Bernardin Cancer Center, Loyola Outpatient Center, Center for Heart & Vascular Medicine and Loyola Oral Health Center as well as the LUC Stritch School of Medicine, the LUC Marcella Niehoff School of Nursing and the Loyola Center for Fitness. Loyola's Gottlieb Memorial Hospital campus in Melrose Park includes the 264-bed community hospital, the Gottlieb Center for Fitness and the Marjorie G. Weinberg Cancer Care Center.
Nora Dudley | EurekAlert!
Novel anti-cancer nanomedicine for efficient chemotherapy
17.09.2019 | University of Helsinki
Researchers have identified areas of the retina that change in mild Alzheimer's disease
16.09.2019 | Universidad Complutense de Madrid
Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Hamburg and the European Molecular Biology Laboratory (EMBL) outstation in the city have developed a new method to watch biomolecules at work. This method dramatically simplifies starting enzymatic reactions by mixing a cocktail of small amounts of liquids with protein crystals. Determination of the protein structures at different times after mixing can be assembled into a time-lapse sequence that shows the molecular foundations of biology.
The functions of biomolecules are determined by their motions and structural changes. Yet it is a formidable challenge to understand these dynamic motions.
At the International Symposium on Automotive Lighting 2019 (ISAL) in Darmstadt from September 23 to 25, 2019, the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, a provider of research and development services in the field of organic electronics, will present OLED light strips of any length with additional functionalities for the first time at booth no. 37.
Almost everyone is familiar with light strips for interior design. LED strips are available by the metre in DIY stores around the corner and are just as often...
Later during this century, around 2060, a paradigm shift in global energy consumption is expected: we will spend more energy for cooling than for heating....
Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Potsdam (both in Germany) and the University of Toronto (Canada) have pieced together a detailed time-lapse movie revealing all the major steps during the catalytic cycle of an enzyme. Surprisingly, the communication between the protein units is accomplished via a water-network akin to a string telephone. This communication is aligned with a ‘breathing’ motion, that is the expansion and contraction of the protein.
This time-lapse sequence of structures reveals dynamic motions as a fundamental element in the molecular foundations of biology.
Two research teams have succeeded simultaneously in measuring the long-sought Thorium nuclear transition, which enables extremely precise nuclear clocks. TU Wien (Vienna) is part of both teams.
If you want to build the most accurate clock in the world, you need something that "ticks" very fast and extremely precise. In an atomic clock, electrons are...
10.09.2019 | Event News
04.09.2019 | Event News
29.08.2019 | Event News
17.09.2019 | Materials Sciences
17.09.2019 | Health and Medicine
17.09.2019 | Ecology, The Environment and Conservation