A new analysis finds that compared to Caucasians, African-Americans with systemic scleroderma have more antibodies in the blood that are linked to severe complications and an increased likelihood of death. They say this finding, published today in Arthritis & Rheumatism, suggests physicians can use these disease markers to screen and treat scleroderma patients proactively.
For the study, Georgetown University Medical Center (GUMC) teamed up with researchers from the University of Pittsburgh School of Medicine to examine 35 years of data collected about the autoimmune disease.
According to the Scleroderma Foundation, there are an estimated 300,000 people in the United States who have scleroderma and about one third of them have the systemic form. While both localized and systemic scleroderma cause hardening of the skin, systemic scleroderma also causes damage to the blood vessels, muscles, and internal organs. Scleroderma occurs when a person's immune system mistakenly attacks and destroys healthy body tissue.
Previous studies suggest that systemic scleroderma is more common, occurs at a younger age and is more severe in African-Americans than Caucasians. Researchers set out to examine if there was a difference in antibodies found in the blood to see if that might explain why African-Americans with the disease often do worse.
Virginia D. Steen, M.D., professor of medicine at GUMC, and her colleagues at Pittsburgh analyzed data from the Pittsburgh Scleroderma Database. Steen helped develop the database,which includes demographic, clinical, autoantibody, organ involvement and survival information for 203 African-American and 2945 Caucasian scleroderma patients seen at the University of Pittsburgh Medical Center between 1972 and 2007.
"Our findings show that African-Americans were more likely to have certain antibodies linked to severe complications such as severe pulmonary fibrosis and gastrointestinal involvement," explains Steen. "These complications tend to be the culprit for people who die from severe cases of scleroderma."
The findings show that African-Americans had higher frequencies of certain scleroderma specific autoantibodies compared to Caucasians: anti-U3-RNP (40 percent vs. 2 percent), U1-RNP (16 percent vs. 7 percent) and anti-topoisomerase (27 percent vs. 21 percent). Anti-topoisomerase auto-antibodies in scleroderma are associated with a higher incidence of pulmonary fibrosis (scarring of the lungs) and greater disease severity, and in this study, African-American patients with this antibody had more frequent and more severe fibrosis than the Caucasians with this antibody.
Pulmonary fibrosis was also more severe in African-American patients with anti-U1 RNP auto-antibodies compared to Caucasian patients with this antibody but a difference in survival between the races was not apparent. Researchers determined that the auto-antibody anti-U3 RNP was linked to more severe gastrointestinal involvement in blacks compared to Caucasians.
"This information can help empower patients and their doctors to act more aggressively, if appropriate, when the person with scleroderma has these antibodies associated with worse outcomes," concludes Steen. "We believe early aggressive intervention will improve outcomes."
In addition to Steen, authors include Robyn T. Domsic, Mary Lucas, Noreen Fertig, Thomas A. Medsger, Jr., of the University of Pittsburgh School of Medicine. Funding for the database has been received from the American College of Rheumatology, Scleroderma Foundation and numerous other grants from foundations and organizations. Steen and her co-authors report having no personal financial interests related to the study.About Georgetown University Medical Center
Karen Mallet | EurekAlert!
Diabetes mellitus: A risk factor for early colorectal cancer
27.05.2020 | Nationales Centrum für Tumorerkrankungen (NCT) Heidelberg
Ultra-thin fibres designed to protect nerves after brain surgery
27.05.2020 | Martin-Luther-Universität Halle-Wittenberg
In living cells, enzymes drive biochemical metabolic processes enabling reactions to take place efficiently. It is this very ability which allows them to be used as catalysts in biotechnology, for example to create chemical products such as pharmaceutics. Researchers now identified an enzyme that, when illuminated with blue light, becomes catalytically active and initiates a reaction that was previously unknown in enzymatics. The study was published in "Nature Communications".
Enzymes: they are the central drivers for biochemical metabolic processes in every living cell, enabling reactions to take place efficiently. It is this very...
Early detection of tumors is extremely important in treating cancer. A new technique developed by researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue. The work is published May 25 in the journal Nature Nanotechnology.
researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from...
Microelectronics as a key technology enables numerous innovations in the field of intelligent medical technology. The Fraunhofer Institute for Biomedical Engineering IBMT coordinates the BMBF cooperative project "I-call" realizing the first electronic system for ultrasound-based, safe and interference-resistant data transmission between implants in the human body.
When microelectronic systems are used for medical applications, they have to meet high requirements in terms of biocompatibility, reliability, energy...
Thomas Heine, Professor of Theoretical Chemistry at TU Dresden, together with his team, first predicted a topological 2D polymer in 2019. Only one year later, an international team led by Italian researchers was able to synthesize these materials and experimentally prove their topological properties. For the renowned journal Nature Materials, this was the occasion to invite Thomas Heine to a News and Views article, which was published this week. Under the title "Making 2D Topological Polymers a reality" Prof. Heine describes how his theory became a reality.
Ultrathin materials are extremely interesting as building blocks for next generation nano electronic devices, as it is much easier to make circuits and other...
Scientists took a leukocyte as the blueprint and developed a microrobot that has the size, shape and moving capabilities of a white blood cell. Simulating a blood vessel in a laboratory setting, they succeeded in magnetically navigating the ball-shaped microroller through this dynamic and dense environment. The drug-delivery vehicle withstood the simulated blood flow, pushing the developments in targeted drug delivery a step further: inside the body, there is no better access route to all tissues and organs than the circulatory system. A robot that could actually travel through this finely woven web would revolutionize the minimally-invasive treatment of illnesses.
A team of scientists from the Max Planck Institute for Intelligent Systems (MPI-IS) in Stuttgart invented a tiny microrobot that resembles a white blood cell...
19.05.2020 | Event News
07.04.2020 | Event News
06.04.2020 | Event News
29.05.2020 | Materials Sciences
29.05.2020 | Materials Sciences
29.05.2020 | Power and Electrical Engineering