Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

How well does clot-busting drug work in stroke patients?

10.11.2010
The clot-busting drug rt-PA remains the most beneficial proven emergency treatment for strokes caused by blood clots, according to an editorial in the November issue of Archives of Neurology by Dr. José Biller.

"The benefits of treatment outweigh the risks in patients treated with intravenous rt-PA within 4.5 hours of symptom onset," Biller wrote. Biller is chairman of the Department of Neurology at Loyola University Chicago Stritch School of Medicine and an internationally recognized expert on stroke care.

Most strokes are ischemic, meaning they are caused by blood clots that block blood flow in the brain. Brain cells begin dying when they are starved of blood supply. But if administered soon enough, an IV drug known as recombinant tissue plasminogen activator (rt-PA) can dissolve clots, restore blood flow and limit damage.

Biller's editorial is about a study, published in the same issue, by Dr. Ioan-Paul Muresan and colleagues at Assistance Publique -- Hopitaux de Paris. The study found that stroke patients who show improvement within one hour of receiving rt-PA were more likely to do well three months later,

Researchers followed 120 patients who received rt-PA and found that 22 (18.3 percent) showed significant improvement within one hour of treatment. After three months, 15 of these patients (68.2 percent) had a favorable outcome. By comparison, only 29.6 percent of patients who did not show early improvement had a favorable outcome at three months.

These findings suggest that a quick bedside assessment "can predict good response," Biller wrote. Conversely, a poor response in the first hour can predict a poor outcome at three months. In such cases, physicians "can begin consideration of mechanical interventions, intra-arterial therapy or other alternative therapies."

Additional studies involving larger populations at multiple centers "are needed to address the significance and clinical utility of the intriguing findings of this carefully conducted study," Biller wrote.

Jim Ritter | EurekAlert!
Further information:
http://www.lumc.edu

More articles from Health and Medicine:

nachricht Why might reading make myopic?
18.07.2018 | Universitätsklinikum Tübingen

nachricht Unique brain 'fingerprint' can predict drug effectiveness
11.07.2018 | McGill University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

NYSCF researchers develop novel bioengineering technique for personalized bone grafts

18.07.2018 | Life Sciences

Machine-learning predicted a superhard and high-energy-density tungsten nitride

18.07.2018 | Materials Sciences

Why might reading make myopic?

18.07.2018 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>