The “disease with 1000 faces” is how multiple sclerosis (MS) is sometimes described. The reason for this name is that the clinical picture can differ dramatically from patient to patient – in terms of both the progression of the disease and the symptoms suffered.
They infected mice in the laboratory with a specific species of bacteria – listeria –, which shares a protein with oligodendrocytes, and observed the consequences when peripheral parts of the body were infected and when the infection was confined to the brain.
A kind of “trade-off” seems to be responsible for the difference in progression. The brain’s “decision” to allow the attack helps combat the pathogen. It would appear that the brain is applying the motto: better that a few infected cells are destroyed and nerve cell extensions are demyelized than that the pathogen spreads and may therefore kill the sufferer. However, in the absence of an infection with menacing pathogens, the brain “recognizes” that this is a misguided attack by killer T cells and destroys them. It is possible, though, that the brain may sometimes “overestimate” the threat posed by a microbial pathogen and may sacrifice the protective myelin sheath unnecessarily.Next steps
Gunnar Bartsch | idw
The genes are not to blame
20.07.2018 | Technische Universität München
Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
20.07.2018 | Power and Electrical Engineering
20.07.2018 | Information Technology
20.07.2018 | Materials Sciences