Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Some breast cancer tumors may be resistant to a common chemotherapy treatment

28.03.2012
University of Alberta medical research suggests there may be a marker to predict which women won't respond to taxane chemotherapy

Some breast cancer tumours may be resistant to a common chemotherapy treatment, suggests recent medical research at the University of Alberta.

Principal investigator Ing Swie Goping and her team discovered some breast cancer tumours had low levels of certain genes, and that those tumours didn't respond well to taxane chemotherapy, a common treatment used in breast cancer.

"These tumours didn't shrink and were resistant to a common chemotherapy treatment. These results give us a strong incentive to continue our research," she said.

Goping and her team looked at tumour samples from 24 patients who had breast cancer. These patients were treated with chemotherapy before surgery. The team discovered four genes in the 'survival' system of tumour cells weren't functioning well in some of the samples. When parts of this system don't work the way they are supposed to, the tumour survival system gets weaker.

Researchers expected that because this survival system was weaker in some tumours, that chemotherapy treatment would be more effective at shrinking these tumours. But the opposite happened.

Instead, they found that the stronger the tumours' survival system was, the better the chemotherapy worked.

"This discovery was a bit of a surprise," said Goping, a researcher in both the Department of Biochemistry and the Department of Oncology.

"One would expect that tumour cells with strong survival systems would be more chemotherapy-resistant, but that's not what we discovered."

Goping noted this research was purely curiosity-driven, and the finding underscores the importance of basic research.

"It was a question we were asking at a very basic level and it turns out the discovery could be clinically relevant. At the moment there is no tool to determine which women would be good candidates for taxane chemotherapy. And chemotherapy resistance is a major clinical problem."

Goping hopes to continue this research by examining tumour samples from thousands of patients over a span of at least three years, in hopes of confirming what the team discovered is indeed a 'marker' that will predict which breast cancer patients will respond well to taxane chemotherapy.

She noted it would be years before doctors would be able to actually start testing breast cancer patients for this marker.

The Canadian Breast Cancer Foundation – Prairies/NWT Region and Alberta Innovates – Health Solutions funded the research, which was published in the peer-reviewed journal Oncogene.

Raquel Maurier | EurekAlert!
Further information:
http://www.ualberta.ca

More articles from Health and Medicine:

nachricht Diabetes mellitus: A risk factor for early colorectal cancer
27.05.2020 | Nationales Centrum für Tumorerkrankungen (NCT) Heidelberg

nachricht Ultra-thin fibres designed to protect nerves after brain surgery
27.05.2020 | Martin-Luther-Universität Halle-Wittenberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Biotechnology: Triggered by light, a novel way to switch on an enzyme

In living cells, enzymes drive biochemical metabolic processes enabling reactions to take place efficiently. It is this very ability which allows them to be used as catalysts in biotechnology, for example to create chemical products such as pharmaceutics. Researchers now identified an enzyme that, when illuminated with blue light, becomes catalytically active and initiates a reaction that was previously unknown in enzymatics. The study was published in "Nature Communications".

Enzymes: they are the central drivers for biochemical metabolic processes in every living cell, enabling reactions to take place efficiently. It is this very...

Im Focus: New double-contrast technique picks up small tumors on MRI

Early detection of tumors is extremely important in treating cancer. A new technique developed by researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue. The work is published May 25 in the journal Nature Nanotechnology.

researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from...

Im Focus: I-call - When microimplants communicate with each other / Innovation driver digitization - "Smart Health“

Microelectronics as a key technology enables numerous innovations in the field of intelligent medical technology. The Fraunhofer Institute for Biomedical Engineering IBMT coordinates the BMBF cooperative project "I-call" realizing the first electronic system for ultrasound-based, safe and interference-resistant data transmission between implants in the human body.

When microelectronic systems are used for medical applications, they have to meet high requirements in terms of biocompatibility, reliability, energy...

Im Focus: When predictions of theoretical chemists become reality

Thomas Heine, Professor of Theoretical Chemistry at TU Dresden, together with his team, first predicted a topological 2D polymer in 2019. Only one year later, an international team led by Italian researchers was able to synthesize these materials and experimentally prove their topological properties. For the renowned journal Nature Materials, this was the occasion to invite Thomas Heine to a News and Views article, which was published this week. Under the title "Making 2D Topological Polymers a reality" Prof. Heine describes how his theory became a reality.

Ultrathin materials are extremely interesting as building blocks for next generation nano electronic devices, as it is much easier to make circuits and other...

Im Focus: Rolling into the deep

Scientists took a leukocyte as the blueprint and developed a microrobot that has the size, shape and moving capabilities of a white blood cell. Simulating a blood vessel in a laboratory setting, they succeeded in magnetically navigating the ball-shaped microroller through this dynamic and dense environment. The drug-delivery vehicle withstood the simulated blood flow, pushing the developments in targeted drug delivery a step further: inside the body, there is no better access route to all tissues and organs than the circulatory system. A robot that could actually travel through this finely woven web would revolutionize the minimally-invasive treatment of illnesses.

A team of scientists from the Max Planck Institute for Intelligent Systems (MPI-IS) in Stuttgart invented a tiny microrobot that resembles a white blood cell...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Dresden Nexus Conference 2020: Same Time, Virtual Format, Registration Opened

19.05.2020 | Event News

Aachen Machine Tool Colloquium AWK'21 will take place on June 10 and 11, 2021

07.04.2020 | Event News

International Coral Reef Symposium in Bremen Postponed by a Year

06.04.2020 | Event News

 
Latest News

Black nitrogen: Bayreuth researchers discover new high-pressure material and solve a puzzle of the periodic table

29.05.2020 | Materials Sciences

Argonne researchers create active material out of microscopic spinning particles

29.05.2020 | Materials Sciences

Smart windows that self-illuminate on rainy days

29.05.2020 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>