A research group of the Tübingen University Hospital studied a small, body-derived molecule called di-methyl fumarate (DMF), hat is the first molecule improving both diseases psoriasis and multiple sclerosis. They found that this body-derived molecule strongly influences natures most potent ‘immune stimulators’, the dendritic cells that have recently been awarded by the Nobel Prize to Ralph Steinman.
Normally, dendritic cells should recognize danger caused by bacteria or viruses, alarm the immune system and raise protective responses. Unfortunately, when fooled, dendritic cells induce by error immunity against the body’s own cells and start to destroy them.The Tübingen team has now shown, that small molecules like DMF re-educate the dendritic cells and turn them into a cell that protects from tissue destruction, the so-called ‚type 2 dendritic cells’. Using complex series of experiments, they uncover the mechanisms underly-ing this ‘re-education of the dendritic cells’. This establishes general rules for the develop-ment of new, most likely safe drugs that will significantly improve the life of patients with se-vere autoimmune diseases, namely psoriasis or multiple sclerosis.
The University of Tübingen holds a patent on this principle.Published in the Journal of Experimental Medicine 2011, October online
Dr. Ellen Katz | idw
Photoactive bacteria bait may help in fight against MRSA infections
12.10.2018 | Purdue University
15 emerging technologies that could reduce global catastrophic biological risks
10.10.2018 | Johns Hopkins Center for Health Security
Augsburg chemists present a new technology for compressing, storing and transporting highly volatile gases in porous frameworks/New prospects for gas-powered vehicles
Storage of highly volatile gases has always been a major technological challenge, not least for use in the automotive sector, for, for example, methane or...
When we put water in a freezer, water molecules crystallize and form ice. This change from one phase of matter to another is called a phase transition. While this transition, and countless others that occur in nature, typically takes place at the same fixed conditions, such as the freezing point, one can ask how it can be influenced in a controlled way.
We are all familiar with such control of the freezing transition, as it is an essential ingredient in the art of making a sorbet or a slushy. To make a cold...
Thin organic layers provide machines and equipment with new functions. They enable, for example, tiny energy recuperators. In future, these will be installed...
Das Zusammenspiel aus Struktur und Dynamik bestimmt die Funktion von Proteinen, den molekularen Werkzeugen der Zelle. Durch Fortschritte in der...
New measurement method allows researchers to precisely follow the movement of individual molecules over long periods of time
The function of proteins – the molecular tools of the cell – is governed by the interplay of their structure and dynamics. Advances in electron microscopy have...
02.10.2018 | Event News
01.10.2018 | Event News
21.09.2018 | Event News
15.10.2018 | Physics and Astronomy
15.10.2018 | Life Sciences
15.10.2018 | Life Sciences