Late in the course of the disease, when the prostate cancer has spread, most patients are given hormone therapy. This reduces the production of the male sex hormone and the tumour shrinks.
"The problem is that the effect is transient," says molecular biologist Heléne Gustavsson, who wrote the thesis. "Sooner or later the tumour will develop resistance to the hormone treatment and then the cancer will continue to grow, often as secondary tumours in the bones."
Tumours have to make new blood vessels if they are to grow and spread in the body. The thesis shows that the tumours that have relapsed after a patient has been given hormone therapy contain more blood vessels. The blood vessels often also look different to how they looked during the earlier stages of the disease.
Another interesting finding is that levels of a protein known as ADAMTS1 are lower in these aggressive tumours. This protein is known to inhibit the growth of blood vessels. Low levels of the protein in the tumours are associated with more blood vessels and a greater spread of the cancer.
"If we can prevent the tumour from making new blood vessels, we can also prevent the cancer from spreading," says Gustavsson. "Now that we have a better understanding of how the formation of blood vessels is controlled in this stage of prostate cancer, we are in a better position to develop medicines that suppress the formation of new vessels in hormone-resistant prostate cancer."
The research team at the Sahlgrenska Academy will now assess how these changes affect the function of the blood vessels and their sensitivity to different treatments.
Every year around 9,000 cases of prostate cancer are diagnosed in Sweden (total population: 9 M people), making it the most common form of cancer. Many of the tumours grow very slowly and have no symptoms, but prostate cancer can also be more aggressive and spread to the lymph nodes and bones. If the cancer is diagnosed early, the entire prostate gland is often removed. Other treatments include radiotherapy and hormone therapy.
For more information, please contact:
Heléne Gustavsson, tel: +46 31 342 29 28, mobile: +46 70 858 26 81, e-mail firstname.lastname@example.org
Thesis for the degree of Doctor of Philosophy (Medicine) at the Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy
Title of thesis: Androgen-Independent Prostate Cancer - studies on angiogenesis and ADAMTS1
The thesis has been successfully defended.
25.09.2018 | Medical University of South Carolina
Artificial intelligence to improve drug combination design & personalized medicine
25.09.2018 | SLAS (Society for Laboratory Automation and Screening)
Our brain is a complex network with innumerable connections between cells. Neuronal cells have long thin extensions, so-called axons, which are branched to increase the number of interactions. Researchers at the Max Planck Institute of Biochemistry (MPIB) have collaborated with researchers from Portugal and France to study cellular branching processes. They demonstrated a novel mechanism that induces branching of microtubules, an intracellular support system. The newly discovered dynamics of microtubules has a key role in neuronal development. The results were recently published in the journal Nature Cell Biology.
From the twigs of trees to railroad switches – our environment teems with rigid branched objects. These objects are so omnipresent in our lives, we barely...
The Fraunhofer FEP has been involved in developing processes and equipment for cleaning, sterilization, and surface modification for decades. The CleanHand Network for development of systems and technologies to clean surfaces, materials, and objects was established in May 2018 to bundle the expertise of many partnering organizations. As a partner in the CleanHand Network, Fraunhofer FEP will present the Network and current research topics of the Institute in the field of hygiene and cleaning at the parts2clean trade fair, October 23-25, 2018 in Stuttgart, at the booth of the Fraunhofer Cleaning Technology Alliance (Hall 5, Booth C31).
Test reports and studies on the cleanliness of European motorway rest areas, hotel beds, and outdoor pools increasingly appear in the press, especially during...
The building blocks of matter in our universe were formed in the first 10 microseconds of its existence, according to the currently accepted scientific picture. After the Big Bang about 13.7 billion years ago, matter consisted mainly of quarks and gluons, two types of elementary particles whose interactions are governed by quantum chromodynamics (QCD), the theory of strong interaction. In the early universe, these particles moved (nearly) freely in a quark-gluon plasma.
This is a joint press release of University Muenster and Heidelberg as well as the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt.
Then, in a phase transition, they combined and formed hadrons, among them the building blocks of atomic nuclei, protons and neutrons. In the current issue of...
Thin-film solar cells made of crystalline silicon are inexpensive and achieve efficiencies of a good 14 percent. However, they could do even better if their shiny surfaces reflected less light. A team led by Prof. Christiane Becker from the Helmholtz-Zentrum Berlin (HZB) has now patented a sophisticated new solution to this problem.
"It is not enough simply to bring more light into the cell," says Christiane Becker. Such surface structures can even ultimately reduce the efficiency by...
A study in the journal Bulletin of Marine Science describes a new, blood-red species of octocoral found in Panama. The species in the genus Thesea was discovered in the threatened low-light reef environment on Hannibal Bank, 60 kilometers off mainland Pacific Panama, by researchers at the Smithsonian Tropical Research Institute in Panama (STRI) and the Centro de Investigación en Ciencias del Mar y Limnología (CIMAR) at the University of Costa Rica.
Scientists established the new species, Thesea dalioi, by comparing its physical traits, such as branch thickness and the bright red colony color, with the...
21.09.2018 | Event News
03.09.2018 | Event News
27.08.2018 | Event News
26.09.2018 | Life Sciences
26.09.2018 | Trade Fair News
26.09.2018 | Life Sciences