Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Benefits of radionuclide therapy for neuroendocrine tumors

21.09.2011
Therapy shows improvement in quality of life and reduction of tumor size

According to new Dutch research featured in the September issue of The Journal of Nuclear Medicine, a peptide receptor radiolabeled therapy (PRRT), [177Lu-DOTA0,Tyr3]Octreotate (177Lu-octreotate) , is effective not only in decreasing tumor size but also in reducing the severity of side effects that often accompany a cancer diagnosis. While many neuroendocrine cancers are incurable, they grow relatively slowly, and life expectancy is relatively long, making quality of life an important factor in treatment.

In particular, the study "Quality of Life in 265 Patients with Gastroenteropancreatic or Bronchial Neuroendocrine Tumors Treated with [177Lu-DOTA0,Try3]Octreotate" focused on gastroenteropancreatic or bronchial neuroendocrine tumors. These tumors are relatively rare neoplasms that derive from the neuroendocrine system; they affect approximately 1-2.5 individuals per 100,000. Since they often have unpredictable biological behavior, the time from discovery to final diagnosis of the tumors is frequently delayed.

"In patients with gastroenteropancreatic or bronchial neuroendocrine tumors, median progression-free survival after therapy with 177Lu-octreotate is 40 months. Such a survival is promising only if the years that are gained are free of serious side-effects or symptoms that affect quality of life," said Saima Khan, MD, lead author of the study. "We showed that the years gained after this therapy show an improved quality of life, as judged by the patients themselves, according to a validated questionnaire. Moreover, this type of treatment lacks most of the serious adverse events and symptoms that are typical with chemotherapeutic agents."

For the study, 265 patients with gastroenteropancreatic or bronchial neuroendocrine tumors were treated with the radiolabeled pharmaceutical 177Lu-octreotate. Follow-up visits were scheduled at fixed time points: six weeks, three months and six months after the last treatment cycle and biannually thereafter. In addition to imaging scans and blood work, patients also completed the European Organisation for Research and Treatment of Cancer quality of life questionnaire—which measures levels of fatigue, nausea plus vomiting, pain, shortness of breath, insomnia, appetite loss, constipation and diarrhea, as well as physical, emotional, role, cognitive and social functioning—at each visit. A baseline questionnaire also was completed prior to therapy.

Computer tomography and magnetic resonance imaging were utilized to categorize tumor response into three groups—a remission group, a stable disease group and a progressive disease group. Among all groups, significant improvement in emotional and social functioning, insomnia, appetite loss and diarrhea was noted. The most important improvements, such as diarrhea, pain, nausea and vomiting, were observed in patients who had tumor regression after therapy with 177Lu-octreotate, which suggests that the improvement was a direct result of the treatment.

"It seems highly desirable that in future studies on the efficacy of antitumor agents—whether with radiopharmaceuticals or other drugs—quality of life evaluation forms be part of the evaluation of overall efficacy," noted Khan.

Authors of the article "Quality of Life in 265 Patients with Gastroenteropancreatic or Bronchial Neuroendocrine Tumors Treated with [177Lu-DOTA0,Tyr3]Octreotate" include: Saima Khan, Eric P. Krenning, Martijn van Essen, Boen L. Kam, Jaap J. Teunissen and Dik J. Kwekkeboom, Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

Susan Martonik | EurekAlert!
Further information:
http://www.snm.org

More articles from Health and Medicine:

nachricht The genes are not to blame
20.07.2018 | Technische Universität München

nachricht Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes

20.07.2018 | Power and Electrical Engineering

Reversing cause and effect is no trouble for quantum computers

20.07.2018 | Information Technology

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern

20.07.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>