Now, researchers have discovered that GERD is associated with global alteration of the microbiome in the esophagus.
The findings, reported in the August 1, 2009 issue of Gastroenterology, may provide for the foundation for further study of the condition as a microecological disease with new treatment possibilities.
The findings of an altered microbiome may have profound implications for treating diseases of the esophagus, among the most common disorders affecting Western populations. In fact, about 40% of adults experience heartburn symptoms at least once a month. Chronic inflammation associated with GERD can lead to the development of Barrett’s esophagus, precancerous condition. The incidence of cancer of the esophagus has increased six-fold since the 1970s--the fastest increasing cancer in the Western world.
“These findings have opened a new approach to understanding the pathogenesis of reflux-related disorders,” states Zhiheng Pei, MD, PhD, assistant professor of pathology and medicine at NYU Langone Medical Center and lead author of the study. “At this time, we don’t yet know whether the changes in bacterial populations are triggering GERD or are simply a response to it. But if changes in the bacterial population do indeed cause reflux, it may be possible to design new therapies with antibiotics, probiotic bacteria or prebiotics.”
Researchers collected and sequenced bacteria from the esophagus of 34 patients, both healthy and those suffering from GERD (specifically esophagitis and Barrett’s esophagus). They found a high concentration of Streptococcus in the esophagus of healthy patients. In contrast, an altered type of microbiome dominated by Gram-negative bacteria was contained in greater proportions in those patients with esophagitis and Barrett’s esophagus.
The human microbiome is comprised of all the microorganisms that reside in or on the human body, as well as all their DNA, or genomes. Microbial cells in the human body are estimated to outnumber human cells by a factor of ten to one. These communities, or microbiomes, however remain largely unstudied, leaving almost entirely unknown their influence upon human development, physiology, immunity and nutrition.
In order to analyze the makeup of these microbial organisms, the National Institutes of Health (NIH) launched the Human Microbiome Project in 2007 and awarded $115 million in research grants over five years to examine the relationship between the microbiome in a specific niche in the body to a particular disease. This study was sponsored by the NIH to examine how changes in microbioal populations correlate with changes in human health.About NYU Langone Medical Center
Dorie Klissas | Newswise Science News
Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
Foods of the future
15.08.2018 | Georg-August-Universität Göttingen
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Physics and Astronomy
17.08.2018 | Information Technology
17.08.2018 | Life Sciences