Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A new material for regenerative medicine capable to control cell immune response

04.11.2019

Scientists of Tomsk Polytechnic University jointly with the University of Montana (USA) proposed a new promising material for regenerative medicine for recovery of damaged tissues and blood vessels.

In this case, such an irritant is a regenerative material. According to scientists, the proposed solution is a simpler way to control the immune response compared to existing ones. The results were published in ACS Biomaterials Science & Engineering (IF: 4,511; Q1).


Mechanism of the developed materials: composite scaffolds from polycaprolactone release the IQ-1 inhibitor and suppress the inflammatory response of immune cells.

Credit: Tomsk Polytechnic University

"Nowadays, researchers have only a few tools to regulate the immune response. You can work with proteins, but it is difficult. You can use compounds, capable of killing immune cells, but they are harmful to other cells.

We followed a different path and suggest using inhibitors placed directly in the material itself to recover damage." - Ksenia Stankevich, author of the article and engineer of the Laboratory for Plasma Hybrid Systems, says.

Scaffolds are 3D frames of thin polymer fibers interwoven with each other in different directions. In regenerative medicine, they are used in case of injuries of bone and soft tissues. They are placed in the damaged area and new tissue regenerates through the scaffold and fills the injured area.

TPU and the University of Montana used a biodegradable polycaprolactone polymer for their scaffolds. It makes products more flexible and affordable in comparison with alternatives. The scaffolds made of polycaprolactone were created by the method of electrospinning, producing thinnest fibers from a polymer solution under the electric field. At the stage of obtaining the scaffolds, we introduce inhibitors into the polymer structure. These are two compounds - IQ-1 (full name - 11H-indeno [1,2-b] quinoxaline-11-on oxime) and IQ-1E (full name - 11H-indeno [1,2-b] quinoxaline-11- on O-(O-ethylcarboxymethyl) oxime).

"Inhibitors suppress or slow down physiological and physicochemical processes. They affect enzymes. To do this, the enzyme and the inhibitor must fit together like a lock and a key. One of the groups of enzymes responsible for the inflammatory process is the JNK group" - Ksenia Stankevich explains. "Earlier we obtained new promising inhibitors, demonstrating high biological activity in inhibiting the functioning of these enzymes, such as IQ-1 and IQ-1E. Our scaffolds differ in the use of specific inhibitors and also in the fact that we can release them from the material gradually, having a prolonged effect. This is mainly due to the gradual natural degradation of the polymer. Additionally, it degrades to biocompatible 6-hydroxycaproic acid, which is recycled by human body.

Immune response of a cell is a cascade of biochemical processes. In this case, the JNK enzymes are links in the chain. Inhibitors bind to enzymes and block their work. Thus, suppressing one link, we turn off the entire subsequent reaction chain.

"In this article, we present the research results on immune cells, isolated from human blood and cell lines. In the future, we will look for opportunities for in vivo research.

Eventually, our scaffolds could be used to recover damages of soft tissues and blood vessels. The polycaprolactone has all suitable mechanical properties. For instance, it can reduce the negative consequences after a heart attack and stroke, the researcher says.

Scaffolds from various materials are already being implemented into medical practice in developed countries, but it is too early to talk about their widespread application. However, it is only a matter of time, that is why scientists continue searching for the most effective materials and biologically active compounds. "

###

The present work is a result of the collaboration of several TPU research teams headed by Associate Prof. Sergey Tverdokhlebov, the Weinberg Research Center, Prof. Andrey Khlebnikov and Prof. Victor Filimonov, the Kizhner Research Center, and Prof. Mark Quinn, and Igor A. Schepetkin, Senior Research Associate at the Department of Microbiology and Immunology, the University of Montana.

The studies were conducted as the part of Ksenia Stankevich internship under the Fulbright Program and financially supported by the Russian Science Foundation project (No. 17-15-01111) and is a development of the RSF project No. 16-13-10239 - Development and Modeling of Hybrid Biodegradable Scaffolds with Predicted Physicochemical and Immunomodulating Properties for Tissue-Engineering Constructions

Media Contact

Vitalii Sdelnikov
Sdelnikov@tpu.ru
7-382-260-6404

 @TPUnews_en

http://www.tpu.ru/en 

Vitalii Sdelnikov | EurekAlert!
Further information:
https://news.tpu.ru/en/news/2019/11/01/35468/
http://dx.doi.org/10.1021/acsbiomaterials.9b01401

More articles from Health and Medicine:

nachricht New database enhances genomics research collaboration
04.11.2019 | Walter and Eliza Hall Institute

nachricht First structure of human cotransporter protein family member solved
29.10.2019 | UT Southwestern Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Memory Effect at Single-Atom Level

An international research group has observed new quantum properties on an artificial giant atom and has now published its results in the high-ranking journal Nature Physics. The quantum system under investigation apparently has a memory - a new finding that could be used to build a quantum computer.

The research group, consisting of German, Swedish and Indian scientists, has investigated an artificial quantum system and found new properties.

Im Focus: Shedding new light on the charging of lithium-ion batteries

Exposing cathodes to light decreases charge time by a factor of two in lithium-ion batteries.

Researchers at the U.S. Department of Energy's (DOE) Argonne National Laboratory have reported a new mechanism to speed up the charging of lithium-ion...

Im Focus: Visible light and nanoparticle catalysts produce desirable bioactive molecules

Simple photochemical method takes advantage of quantum mechanics

Northwestern University chemists have used visible light and extremely tiny nanoparticles to quickly and simply make molecules that are of the same class as...

Im Focus: An amazingly simple recipe for nanometer-sized corundum

Almost everyone uses nanometer-sized alumina these days - this mineral, among others, constitutes the skeleton of modern catalytic converters in cars. Until now, the practical production of nanocorundum with a sufficiently high porosity has not been possible. The situation has changed radically with the presentation of a new method of nanocorundum production, developed as part of a German-Polish cooperation of scientists from Mülheim an der Ruhr and Cracow.

High temperatures and pressures, processes lasting for even dozens of days. Current methods of producing nanometer-sized alumina, a material of significant...

Im Focus: Structured light promises path to faster, more secure communications

Quantum mechanics is embracing patterns of light to create an alphabet that can be leveraged to build a light-based quantum network

Structured light is a fancy way to describe patterns or pictures of light, but deservedly so as it promises future communications that will be both faster and...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Smart lasers open up new applications and are the “tool of choice” in digitalization

30.10.2019 | Event News

International Symposium on Functional Materials for Electrolysis, Fuel Cells and Metal-Air Batteries

02.10.2019 | Event News

NEXUS 2020: Relationships Between Architecture and Mathematics

02.10.2019 | Event News

 
Latest News

The secret behind crystals that shrink when heated

04.11.2019 | Physics and Astronomy

Worldwide observations confirm nearby 'lensing' exoplanet

04.11.2019 | Physics and Astronomy

A new material for regenerative medicine capable to control cell immune response

04.11.2019 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>