Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A nanofibrous conduit suitable for repair of long-segment sciatic nerve defects

28.10.2013
Autografts or allografts are commonly used in neurosurgery. Unfortunately, autografts have limitations such as body injury, repeated surgeries and disproportion of grafted nerve tissue in terms of size and structure.

In addition, a similar problem, i.e., stimulation of the immune system, will be encountered in transplantation of allografts or xenografts. Some studies used artificial nerve conduits to repair nerve defects.

Among the artificial nerve conduits used, nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) conduits exhibit several advantages. One advantage of these nerve conduits is that they can be bent to an angle of up to 180¢ª and then restore to their original shape, which is necessary for adaptation inside a living system. Moreover, the PHBV conduits have a thin wall and a highly porous structure, which are important determinants for nutrient transport into the conduit. A further advantage is that they can be easily fabricated and rolled to any required length and diameter by heat processing.

Dr. Esmaeil Biazar and team from Islamic Azad University, Tonekabon, Iran used nanofibrous PHBV conduit and autologous sciatic nerve to bridge 30-mm-long rat sciatic nerve gaps. Within 4 months after surgery, rat sciatic nerve functional recovery was evaluated per month by behavioral analyses. Results showed that rat sciatic nerve functional recovery was similar after nanofibrous PHBV conduit and autologous nerve grafting. These findings, published in the Neural Regeneration Research (Vol. 8, No. 27, 2013), suggest that nanofibrous PHBV conduit is suitable in use for repair of long-segment sciatic nerve defects.

Article: " Efficacy of nanofibrous conduits in repair of long- segment sciatic nerve defects," by Esmaeil Biazar1, Saeed Heidari Keshel2, 3, Majid Pouya4 (1 Department of Biomaterial Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran; 2 Student Research Committee, Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3 Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; 4 Faculty of Medical Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran)

Biazar E, Heidari SK, Pouya M. Efficacy of nanofibrous conduits in repair of long-segment sciatic nerve defects. Neural Regen Res. 2013;8(27):2501-2509.

Contact:

Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
http://www.nrronline.org/
Full text: http://www.sjzsyj.org/CN/article/downloadArticleFile.do?attachType=PDF&id=723

Meng Zhao | EurekAlert!
Further information:
http://www.nrren.org

More articles from Health and Medicine:

nachricht The genes are not to blame
20.07.2018 | Technische Universität München

nachricht Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes

20.07.2018 | Power and Electrical Engineering

Reversing cause and effect is no trouble for quantum computers

20.07.2018 | Information Technology

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern

20.07.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>