Findings published in Proceedings of the National Academy of Sciences
Karl Klose, professor of biology and a researcher in UTSA's South Texas Center for Emerging Infectious Diseases, has teamed up with researchers at Ruhr University in Bochum, Germany to understand how humans get infected with cholera, Their findings were released this week in an article published by the Proceedings of the National Academy of Sciences.
Karl Klose, professor of biology and a researcher in UTSA's South Texas Center for Emerging Infectious Diseases, has teamed up with researchers at Ruhr University in Bochum, Germany to understand how humans get infected with cholera. Klose and his collaborators discovered that Vibrio cholerae, which normally lives in oceans and rivers, senses a shift in temperature as it enters the human body through a mechanism called a Ribonucleic Acid (RNA) thermometer. The thermometer detects the higher body temperature of 98.6 degrees Fahrenheit, and then turns on the virulence factors that lead to cholera.
Cholera is an acute infection caused by ingestion of food or water that is contaminated with the bacterium Vibrio cholerae. An estimated three to five million cases are reported annually and 100,000-120,000 people die from cholera infections every year. Cholera patients suffer from dramatic fluid loss and can lose up to 40 liters of fluid from their body in just a few days.
Klose and his collaborators discovered that Vibrio cholerae, which normally lives in oceans and rivers, senses a shift in temperature as it enters the human body through a mechanism called a Ribonucleic Acid (RNA) thermometer.
The thermometer detects the higher body temperature of 98.6 degrees Fahrenheit, and then turns on the virulence factors that lead to cholera. Klose's laboratory showed that interfering with the thermometer prevents the bacteria from causing disease, suggesting possible therapeutic outcomes from this research.
The research collaboration stemmed from a long friendship between Klose and Franz Narberhaus, who trained as microbiologists together at U.C. Berkeley 25 years ago.
"The temperature shift is one of the signals that the bacterium uses to turn on the virulence factors, such as the cholera toxin, that cause the disease," said Klose. "We have shown that the bacteria's thermometer controls temperature-dependent expression of the virulence factors. They only express them when they are at body temperature and not at ocean temperature."
"We found that if the RNA thermometer is prevented from working correctly and detecting the right temperature, the bacteria won't cause any disease at all. The organisms will just pass right through the body," explained Klose. "If you can figure out how to disrupt the RNA thermometer in some manner, then you may have a therapy against this disease."
Klose says the long-term goal is to come up with intervention strategies against cholera. Understanding exactly how the bacterium controls the expression of the virulence factors is one step forward in trying to intervene during cholera epidemics.
The University of Texas at San Antonio (UTSA) is an emerging Tier One research institution specializing in health, energy, security, sustainability, and human and social development. With nearly 29,000 students, it is the largest university in the San Antonio metropolitan region. UTSA advances knowledge through research and discovery, teaching and learning, community engagement and public service. The university embraces multicultural traditions and serves as a center for intellectual and creative resources as well as a catalyst for socioeconomic development and the commercialization of intellectual property – for Texas, the nation and the world.
Kris Rodriguez | Eurek Alert!
Rutgers researchers develop automated robotic device for faster blood testing
14.06.2018 | Rutgers University
Speech comprehension with a cochlear implant
04.06.2018 | Universität zu Lübeck
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
22.06.2018 | Materials Sciences
22.06.2018 | Earth Sciences
22.06.2018 | Life Sciences