Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tear duct implant effective at reducing pain and inflammation in cataract surgery patients

20.10.2014

First-of-its-kind device may solve issue of poor patient compliance with eye drops

The first tear duct implant developed to treat inflammation and pain following cataract surgery has been shown to be a reliable alternative to medicated eye drops, which are the current standard of care, according to a study presented today at AAO 2014, the 118th annual meeting of the American Academy of Ophthalmology. The device, known as a punctum plug, automatically delivers the correct amount of postoperative medication in patients, potentially solving the issue of poor compliance with self-administering eye drops.

After cataract surgery, most patients are prescribed topical eye drops to reduce ocular inflammation that often occurs after surgery, but many do not or are not able to comply with the recommended dosing regimen. To potentially eliminate the issue of compliance, patients who had received cataract surgery from four ophthalmology practices across the United States were selected to participate in this phase 2 study.

The researchers tested punctum plugs designed to deliver a sustained release anti-inflammatory pain medication (dexamethasone) to the eye over a period of 30 days following the removal of cataracts. After 30 days, the plug softens, liquefies and is cleared through the tear duct without the need for removal. The researchers concluded that when compared to a placebo, the dexamethasone punctum plug provides sustained reductions of inflammation and pain for up to one month following cataract surgery.

The 60 participants were randomly split into two groups, with one group of 30 patients receiving a placebo vehicle punctum plug and the other group of 30 patients receiving a dexamethasone-medicated punctum plug. At various points throughout the 30 days following cataract surgery the researchers assessed the number of patients in both groups with ocular inflammation (measured by the presence of anterior chamber cells in the treated eye) and pain.

They found that the medicated plug group had significantly less pain throughout the 30 days. On day one, the placebo group reported a mean ocular pain score more than three times higher than the medicated plug group. By day 14, the placebo group reported a mean ocular pain score 11 times higher than the medicated plug group, remaining at this level through the conclusion of the study.

Ocular inflammation in the medicated plug group was also significantly less than the placebo group throughout the 30 days. By day 14, more than 30 percent of patients in the medicated plug group showed no ocular inflammation, compared to just 3 percent in the placebo group. By day 30 of the study, over 60 percent of the patients in the medicated plug group had no signs of inflammation compared to 13 percent of patients in the placebo group.

Significantly fewer patients in the medicated plug group required additional anti-inflammatory medications compared to those in the placebo group. Furthermore, a lower percentage of the medicated plug group reported experiencing light sensitivity compared with placebo patients at day 1 (44.8 percent vs. 65.5 percent) and day 4 (37.9 percent vs. 56.7 percent).

"Most people who have cataract surgery are older and may have a difficult time adhering to a post-operative eye drop regimen for various reasons," says Thomas Walters, M.D., an ophthalmologist at Texan Eye in Austin, Texas and lead researcher for the study. "Getting eye drops onto the eye can be difficult for anybody, especially those who might have trouble holding the bottle or targeting the drops onto the eye. The punctum plug eliminates those variables and will make recovering from surgery far easier for cataract patients."

Based on the results of this study, the product is being evaluated further in phase 3 clinical trials. This study was supported by Ocular Therapeutix, which developed the dexamethasone punctum plug.

Evaluation of Sustained-Release Dexamethasone for Safety and Efficacy After Cataract Surgery in a Multicenter Study (PA004) was presented at AAO 2014, the 118th annual meeting of the American Academy of Ophthalmology in conjunction with the European Society of Ophthalmology, which is in session October 17-21 at McCormick Place in Chicago. More than 25,000 attendees and 620 companies from 123 countries gather each year to showcase the latest in ophthalmic education, research and technology. To learn more about the place Where All of Ophthalmology Meets, visit http://www.aao.org/2014.

About the American Academy of Ophthalmology The American Academy of Ophthalmology, headquartered in San Francisco, is the world's largest association of eye physicians and surgeons, serving more than 32,000 members worldwide. The Academy's mission is to advance the lifelong learning and professional interests of ophthalmologists to ensure that the public can obtain the best possible eye care. For more information, visithttp://www.aao.org. The Academy is also a leading provider of eye care information to the public. The Academy's EyeSmart® program educates the public about the importance of eye health and empowers them to preserve healthy vision. EyeSmart provides the most trusted and medically accurate information about eye diseases, conditions and injuries. OjosSanos™ is the Spanish-language version of the program. Visit http://www.geteyesmart.org or http://www.ojossanos.org to learn more.

Media Relations | Eurek Alert!

More articles from Medical Engineering:

nachricht Researchers use MRI to predict Alzheimer's disease
20.11.2018 | Radiological Society of North America

nachricht A 15-minute scan could help diagnose brain damage in newborns
15.11.2018 | Imperial College London

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nonstop Tranport of Cargo in Nanomachines

Max Planck researchers revel the nano-structure of molecular trains and the reason for smooth transport in cellular antennas.

Moving around, sensing the extracellular environment, and signaling to other cells are important for a cell to function properly. Responsible for those tasks...

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Optical Coherence Tomography: German-Japanese Research Alliance hosted Medical Imaging Conference

19.11.2018 | Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

 
Latest News

Nonstop Tranport of Cargo in Nanomachines

20.11.2018 | Life Sciences

Researchers find social cultures in chimpanzees

20.11.2018 | Life Sciences

When AI and optoelectronics meet: Researchers take control of light properties

20.11.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>