Breast cancer is the most frequent form of cancer in women. The aim of systematic early detection is to reduce the number of deaths from breast cancer. With help from the North Rhine-Westphalian State Cancer Registry, evaluations were made of 53,375 examinations from the implementation phase of the screening, focusing on the detection of breast cancer in the screening process and at the end of the biennial interval after screenings in which nothing was detected. According to the analyses evidently makes it possible to make diagnoses – also of aggressive subtypes – at an earlier stage. Women who are 60 or older contract breast cancer more often than those between the ages of 50 and 59.
Breast cancer is the most frequent form of cancer in women. The aim of systematic early detection is to reduce the number of deaths from breast cancer. This is why the mammography screening programme has been built up in Germany since 2005, with the aim of offering every woman between the ages of 50 and 69 quality-controlled screening for the early detection of breast cancer.
With help from the North Rhine-Westphalian State Cancer Registry, evaluations were made of 53,375 examinations from the implementation phase of the screening, focusing on the detection of breast cancer in the screening process and at the end of the biennial interval after screenings in which nothing was detected.
From these data, detection rates through early detection mammography screening were established for invasive breast cancer, as well as during the subsequent biennial interval. Based on immunohistochemical examinations, the determination of hormone receptors and the HER2/neu status, subtypes were created with respect to tumour aggressiveness: HER2 positive and triple negative breast carcinomas were defined as being aggressive.
A detailed analysis of aggressive breast cancer among hormone receptor negative and HER2 positive carcinomas shows detection rates which are six times higher – and among triple negative carcinomas twice as high – in the screening than after the biennial interval. Aggressive invasive breast carcinomas have the highest rate of diagnosis in screening among women in the 60-69 age group. The stage distribution of aggressive invasive breast carcinomas is better than after the interval.
According to the scientific analyses mammography screening evidently makes it possible to make diagnoses – also of aggressive subtypes – at an earlier stage. Women who are 60 or older contract breast cancer more often than those between the ages of 50 and 59. “These results provide further evidence that a systematic programme for the early detection of breast cancer makes sense,” says Prof. Walter Heindel from the Reference Centre for Mammography at Münster University Hospital.
PD Dr. med. Stefanie Weigel
Prof. Dr. med. Walter Heindel
Institut für Klinische Radiologie
Referenzzentrum Mammographie am Universitätsklinikum Münster
Albert-Schweitzer-Campus 1 (Gebäude A1),
Prange A, Bokhof B, Polzer P, Tio J, Radke, I, Heidinger O, Heindel W, Weigel S. Higher Detection Rates of Biologically Aggressive Breast Cancers in Mammography Screening than in the Biennial Interval. Fortschr Röntgenstr 2018; DOI:10.1055/a-0657-3970
Dr. Kathrin Kottke | idw - Informationsdienst Wissenschaft
Implantable transmitter provides wireless option for biomedical devices
04.08.2020 | Purdue University
Certainty in just 15 minutes – researchers develop a graphene oxid based rapid test to detect infections
03.08.2020 | Fraunhofer-Institut für Zuverlässigkeit und Mikrointegration IZM
Scientists at the Fraunhofer Institute for Laser Technology ILT have come up with a striking new addition to contact stamping technologies in the ERDF research project ScanCut. In collaboration with industry partners from North Rhine-Westphalia, the Aachen-based team of researchers developed a hybrid manufacturing process for the laser cutting of thin-walled metal strips. This new process makes it possible to fabricate even the tiniest details of contact parts in an eco-friendly, high-precision and efficient manner.
Plug connectors are tiny and, at first glance, unremarkable – yet modern vehicles would be unable to function without them. Several thousand plug connectors...
An international research team has found a new approach that may be able to reduce bone loss in osteoporosis and maintain bone health.
Osteoporosis is the most common age-related bone disease which affects hundreds of millions of individuals worldwide. It is estimated that one in three women...
Traditional single-cell sequencing methods help to reveal insights about cellular differences and functions - but they do this with static snapshots only...
“Core-shell” clusters pave the way for new efficient nanomaterials that make catalysts, magnetic and laser sensors or measuring devices for detecting electromagnetic radiation more efficient.
Whether in innovative high-tech materials, more powerful computer chips, pharmaceuticals or in the field of renewable energies, nanoparticles – smallest...
An international research team with Prof. Cornelia Denz from the Institute of Applied Physics at the University of Münster develop for the first time light fields using caustics that do not change during propagation. With the new method, the physicists cleverly exploit light structures that can be seen in rainbows or when light is transmitted through drinking glasses.
Modern applications as high resolution microsopy or micro- or nanoscale material processing require customized laser beams that do not change during...
23.07.2020 | Event News
21.07.2020 | Event News
07.07.2020 | Event News
06.08.2020 | Earth Sciences
06.08.2020 | Power and Electrical Engineering
06.08.2020 | Life Sciences