Research published in the academic journal, Chemical Communications, reveals that this new compound could be used in a ‘chemically-sensitive MRI scan’ to help identify the extent of progression of diseases such as cancer, without the need for intrusive biopsies.
The researchers, who are part of an Engineering and Physical Sciences Research Council (EPSRC) funded group developing new ways of imaging cancer, have created a chemical which contains fluorine. It could, in theory, be given to the patient by injection before an MRI scan. The fluorine responds differently according to the varying acidity in the body, so that tumours could be highlighted and appear in contrast or ‘light up’ on the resulting scan.
Professor David Parker of Durham University’s Department of Chemistry explained: “There is very little fluorine present naturally in the body so the signal from our compound stands out. When it is introduced in this form it acts differently depending on the acidity levels in a certain area, offering the potential to locate and highlight cancerous tissue.”
Professor Parker’s team is the first to design a version of a compound containing fluorine which enables measurements to be taken quickly enough and to be read at the right ‘frequency’ to have the potential to be used with existing MRI scanners, whilst being used at sufficiently low doses to be harmless to the patient.
Professor Parker continued: “We have taken an important first step towards the development of a selective new imaging method. However, we appreciate that there is a lot of work to do to take this laboratory work and put it into practice. In principle, this approach could be of considerable benefit in the diagnosis of diseases such as breast, liver or prostate cancer.”
Durham University has filed a patent on this new approach and is looking for commercial partners to help develop the research. Professor Parker and his team believe that molecules containing fluorine could be used in mainstream MRI diagnoses within the next decade.
Chris Hiley, Head of Policy and Research Management at The Prostate Cancer Charity, said: “This is interesting work. The researchers are still some way from testing how this new idea might work in people but they are dealing with a knotty and important problem. In prostate cancer in particular more research is needed into cancer imaging as current techniques need improving.
“This development could have applications in many other cancers too. Once transferred from the lab to the bedside this research has potential to help show exactly where cancer may be in the body. This would add certainty to treatment decisions and improve monitoring of cancer progress. Looking even further into the future it could even have some use in improving diagnosis.”
Media and Public Affairs Team | alfa
A first look at interstitial fluid flow in the brain
05.07.2018 | American Institute of Physics
A sentinel to watch over ocular pressure
04.07.2018 | Fraunhofer Institute for Microelectronic Circuits and Systems
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
19.07.2018 | Earth Sciences
19.07.2018 | Power and Electrical Engineering
19.07.2018 | Materials Sciences