The technique, which uses electric fields to build up layers of cells to form a tissue, is being used to create Hematons – aggregates of blood producing cells essential in the function of healthy bone marrow.
Dr Gerard Markx, of the School of Chemical Engineering and Analytical Science, has developed the technique based on a phenomenon called dielectrophoresis.
Dr Markx said: “We have proven this technique works, and have created some very simple Hematon structures in the lab. If we can perfect this technique then it may one day be possible to create artificial bone marrow outside the body and produce any given blood type.”
Dr Markx and his research team, which includes scientists in the University’s Faculty of Life Sciences, have so far created tissue 200 microns thick using the technique.
The function of bone marrow in the body is the production of blood. The most productive part of the bone marrow is formed by the hematon. Hematons are thought to be dysfunctional in patients suffering from bone marrow diseases like leukaemia.
Tissue is made using a series of glass slides with micro-electrodes etched on top of them. A solution containing cells is introduced to the slides. Electric fields are then created between the electrodes by running a small AC current through them.
In a similar way to which iron filings are attracted to the poles of magnets, the cells are attracted to the regions between the electrodes. As the cells collect together layers of cells build up, forming tissue.
Dr Markx said: “The use of electricity enables greater control over the position of the cells than conventional techniques. By varying the voltage and using different electrode shapes, cells can be positioned and stacked on top of each other in any pattern. Different electric fields can also be used to attract different types of cells. Most importantly, cells can be kept alive and active.”
The micro-electrodes used measure between 50-250 microns in size and can be positioned in any formation.
Simon Hunter | alfa
Can radar replace stethoscopes?
14.08.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Novel PET imaging method could track and guide therapy for type 1 diabetes
03.08.2018 | Society of Nuclear Medicine and Molecular Imaging
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
The quality of materials often depends on the manufacturing process. In casting and welding, for example, the rate at which melts solidify and the resulting microstructure of the alloy is important. With metallic foams as well, it depends on exactly how the foaming process takes place. To understand these processes fully requires fast sensing capability. The fastest 3D tomographic images to date have now been achieved at the BESSY II X-ray source operated by the Helmholtz-Zentrum Berlin.
Dr. Francisco Garcia-Moreno and his team have designed a turntable that rotates ultra-stably about its axis at a constant rotational speed. This really depends...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
14.08.2018 | Information Technology
14.08.2018 | Life Sciences
14.08.2018 | Life Sciences