Measuring the biochemical changes in breast tumors with magnetic resonance (MR) spectroscopy enables radiologists to more accurately distinguish benign tumors from cancerous ones, according to a study appearing in the August issue of the journal Radiology.
"Adding spectroscopy to breast MR examinations will not only reduce concern over possible missed cancers and unnecessary biopsy procedures, it may also improve the efficiency and quality of patient care," said co-author Sina Meisamy, M.D., a postdoctoral fellow at the University of Minnesota Center for Magnetic Resonance Research in Minneapolis.
MR imaging of the breasts has a high rate of sensitivity (94 percent – 100 percent) for detecting tumors, but a variable rate of specificity (37 percent – 97 percent) for distinguishing malignant from benign tumors.
MR spectroscopy uses the same magnet and electronics as MR imaging, but with specialized methods that produce a "spectrum" identifying different chemical compounds in the tissues. MR spectroscopy has been shown to be useful for looking at various disorders, including cancer, Alzheimer’s disease, diabetes and certain inflammatory and ischemic diseases. Generally used for the brain, spectroscopy poses no known health risk to patients and typically adds only seven to 10 minutes to the MR procedure.
For the study, four radiologists evaluated 55 breast MR imaging cases that had findings confirmed through earlier biopsies. The evaluations were done with and without MR spectroscopy. The addition of spectroscopy resulted in more cancerous tumors detected (from 87 percent to 94 percent), a higher success rate for distinguishing benign from malignant tumors (from 51 percent to 57 percent) and a greater agreement among the radiologists on their findings. Also, with the addition of spectroscopic readings, two of the four radiologists had significantly improved sensitivity to detect cancerous tumors and all four participants achieved significantly improved accuracy in assigning a probability of malignancy.
"Spectroscopy gives us an additional piece of information about the biochemical composition of the tumor," explained senior author Michael Garwood, Ph.D., associate director of the Center for Magnetic Resonance Research and the Lillian Quist - Joyce Henline Chair in Biomedical Research Professor of Radiology at the University of Minnesota. "When the standard MR imaging exam is inconclusive, the spectroscopy measurement can improve the rate of detecting a cancerous breast tumor."
Doug Dusik | EurekAlert!
Rutgers researchers develop automated robotic device for faster blood testing
14.06.2018 | Rutgers University
Speech comprehension with a cochlear implant
04.06.2018 | Universität zu Lübeck
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
22.06.2018 | Materials Sciences
22.06.2018 | Earth Sciences
22.06.2018 | Life Sciences