Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Precision-Guided Epidurals and Better Blood Monitors

28.05.2014

New Applications for OCT Could Improve Care for Women in Labor and People with Diabetic Retinopathy and Glaucoma

The march of modern medicine is often driven by revolutions in medical imaging. When technology advances, doctors are better able to peer deeply into human tissues, and thus able to detect, diagnose and treat human diseases more effectively.
 
Now, researchers have taken an established imaging technology called “optical coherence tomography,” or OCT, and integrated it with other instruments to bring about the next revolution in imaging by helping doctors provide safer, less painful and more effective care for women in labor and people with diabetic retinopathy and glaucoma. Their research will be presented at CLEO: 2014 being held June 8-13 in San Jose, California, USA.
 
OCT uses scattered “echoes” or reflections of light waves to produce high-resolution images of biological tissues, similar to ultrasound imaging but with one order of magnitude improvement in the resolution. Ophthalmologists have been using OCT to examine the retina for years.


Results of OCT-guided insertion. A)The porcine spine used for experiment. B) Anatomy of lumbar spine (sagittal view). C) Images acquired by GRIN needle device corresponding to different tissues. Credit: Qinggong Tang

More recently, OCT has been applied to a number of other clinical specialties, including oncology for early cancer detection and staging in the gastrointestinal and urogenital tract as well as in cardiology, where it is used to study the formation of plaques in coronary arteries in situ.
 
Precision-guided epidurals  

Bioengineer Yu Chen of the University of Maryland and his colleagues have developed a way to integrate an OCT device with an 18-gauge epidural needle. Epidural administration, Chen notes, is traditionally done blindly, using anatomical landmarks. But the team’s newly miniaturized handheld device lets anesthesiologists see tissue from the perspective of the tip of the epidural needle, which could help doctors to deliver spinal anesthetic to patients with less pain and fewer complications.
 
“Due to lack of visual feedback, failure rates are often high, leading to multiple needle insertions,” he says. Side effects of these failures can include trauma to blood vessels and punctures in the dura, the outermost membrane surrounding the brain and spinal cord.
 
“An OCT forward-imaging probe can provide anesthesiologists with real-time visualization of the microarchitecture of tissues and important landmarks, and thus could significantly improve the accuracy and the safety of the needle-based procedure,” Chen says.
 
The researchers have been successful in testing needle-guidance experiments on pig swine samples and hope to conduct a pre-clinical study of the device within the next year.
 
Presentation AM2O.3, titled “Real-time Epidural Anesthesia Guidance Using Optical Coherence Tomography Needle Probe will take place Monday, June 9, at 11:15 a.m. in Salon V & VI of the San Jose Convention Marriott.
 
Better blood monitors  

A team at the University of California, Davis, led by Biomedical Engineer Vivek Srinivasan has shown how OCT can simultaneously measure blood flow and blood oxygenation in vessels, without the need for contrast agents.
 
Like ultrasound, OCT can provide structural information, but it can also be used to determine flow rates and for angiography, visualizing the interior of blood vessels, says Shau Poh Chong, a postdoctoral researcher in the Srinivasan lab.
 
“Conventional pulse oximetry measures oxygen saturation using transmitted light,” Chong says. “Performing these measurements quantitatively with reflected light has traditionally been difficult due to the unknown distance traveled by the light through scattering tissue.”
 
OCT directly determines the distance that light travels. Until now, however, it was difficult to use OCT to measure oxygen saturation in blood, due to additional modeling errors introduced by light scattering.  At visible wavelengths, scattering is much lower relative to blood absorption than at infrared wavelengths, where OCT is typically performed.  The OCT system developed in the Srinivasan lab uses broadband visible light to measure the amounts of both oxygenated and deoxygenated hemoglobin, the oxygen-carrying protein of blood, thus revealing oxygen saturation levels.  In addition, the team developed new methods to further reduce modeling errors caused by light scattering.
 
“The broad set of measurements provided by the system, including angiography, oximetry and red blood cell flow rates enables the direct assessment of tissue oxygen metabolism, which is essential for understanding the evolution of oxygen supply and demand in numerous disease models,” Chong says. “In the future, these techniques could be applied to study metabolic changes in diseases that affect the human retina, such as diabetic retinopathy and glaucoma.”
 
Presentation ATh1O.2, titled “Optical Coherence Imaging of Microvascular Oxygenation and Hemodynamics will take place Thursday, June 12, at 8:30 a.m. in Willow Glen I - III of the San Jose Convention Marriott.
 
PRESS REGISTRATION: A press room for credentialed press and analysts will be located in the San Jose Convention Center, Sunday through Thursday, June 8-12. Those interested in obtaining a press badge for CLEO: 2014 should contact Lyndsay Meyer at 202.416.1435 or lmeyer@osa.org.
 
About CLEO
With a distinguished history as the industry's leading event on laser science, the Conference on Lasers and Electro-Optics (CLEO) is the premier international forum for scientific and technical optics, uniting the fields of lasers and opto-electronics by bringing together all aspects of laser technology, from basic research to industry applications. CLEO: Expo showcases the latest products and applications from more than 300 participating companies from around the world, providing hands-on demonstrations of the latest market innovations and applications. The Expo also offers valuable on-floor programming, including Market Focus and the Technology Transfer program.

Sponsored by the American Physical Society's (APS) Laser Science Division, IEEE Photonics Society and The Optical Society (OSA), CLEO provides the full range of critical developments in the field, showcasing the most significant milestones from laboratory to marketplace. With an unparalleled breadth and depth of coverage, CLEO connects all of the critical vertical markets in lasers and electro-optics. For more information, visit www.cleoconference.org. CLEO: 2014 takes place June 8 - 13 at the San Jose Convention Center.

Lyndsay Meyer | Eurek Alert!
Further information:
http://www.cleoconference.org/home/news-and-press/cleo-press-releases/precision-guided-epidurals-and-better-blood-monito/

Further reports about: Convention Monitors OCT blood diabetic diseases glaucoma lasers retinopathy spinal wavelengths

More articles from Medical Engineering:

nachricht New insight into the brain’s hidden depths: Jena scientists develop minimally-invasive endoscope
27.11.2018 | Leibniz-Institut für Photonische Technologien e. V.

nachricht New China and US studies back use of pulse oximeters for assessing blood pressure
21.11.2018 | University of British Columbia

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New megalibrary approach proves useful for the rapid discovery of new materials

Northwestern discovery tool is thousands of times faster than conventional screening methods

Different eras of civilization are defined by the discovery of new materials, as new materials drive new capabilities. And yet, identifying the best material...

Im Focus: Data storage using individual molecules

Researchers from the University of Basel have reported a new method that allows the physical state of just a few atoms or molecules within a network to be controlled. It is based on the spontaneous self-organization of molecules into extensive networks with pores about one nanometer in size. In the journal ‘small’, the physicists reported on their investigations, which could be of particular importance for the development of new storage devices.

Around the world, researchers are attempting to shrink data storage devices to achieve as large a storage capacity in as small a space as possible. In almost...

Im Focus: Data use draining your battery? Tiny device to speed up memory while also saving power

The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.

Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

New megalibrary approach proves useful for the rapid discovery of new materials

19.12.2018 | Materials Sciences

Artificial intelligence meets materials science

19.12.2018 | Materials Sciences

Gut microbiome regulates the intestinal immune system, researchers find

19.12.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>