Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Novel coating enables hip implants to grow in better and prevents aseptic inflammation


The number of hip prostheses in the EU has risen steadily over the past ten years – most notably in Austria and Germany with 300 implants per 100,000 inhabitants. The frequency of aseptic inflammatory processes between bone and implant, accompanied with loosening of the prosthesis, has increased, resulting in a shortened lifetime of the hip replacement. A consortium of eleven research and industrial partners led by the Fraunhofer Institute for Production Technology IPT has now joined forces to develop a new generation of endoprosthesis for the treatment of aseptic loosening disease.

EVPRO – short for: Extracellular Vesicles Promoted Regenerative Osseointegration – aims to counteract the shortened lifetime and to reduce the risk of inflammation of hip revision prostheses.

Example for Hip stem implant (Accolade II)

Photo: Stryker European Operations B.V.

The eleven project partners from four countries intend to ensure mobility for elderly patients and improve their quality of life and well-being by diminishing problems associated with implanted joint prosthesis and by reducing the number and frequency of subsequent medical treatments.

The partners expect that EVPRO's results lead to a significant decrease in aseptic loosening in joint replacement.

Biologically active coating enables better implant ingrowth and causes less complications

The objective of EVPRO is to devise innovative biologically active coatings for hip revision endoprosthesis, which are able to control inflammation at the biointerface of the endoprosthesis and promote bone regeneration.

The EVPRO coating combines a novel bioinstructive, adaptive nano-functionalized degradable biomaterial homing extracellular vesicles incorporated in a non-degradable bone-instructive microporous and nano-roughened TiO2 surface.

These coatings are applied at the interface between implant and inflamed tissue, to perceive inflammation and modulate it in a proportional, self-regulating manner.

Additionally, they instruct bone forming cells, so-called osteoblasts, to migrate into the coating to improve osseointegration resulting in a better healing and an increased lifetime of the implant.

In the long term, researchers expect that the number of repeated operations to replace worn implants will decrease, having a direct positive impact on the duration of the necessary hospital stay and the prescription of expensive medication.

The results of the EVPRO research project can thus support the European Union's objectives on active ageing in society and lead to significant improvements in the quality of life for hundreds of thousands of citizens in the EU and beyond.

Dr. Jochen Salber from the Clinic of Surgery of the UMC Knappschaftskrankenhaus Bochum; Hospital of the Ruhr-University Germany says: “The EVPRO technology is still at an early stage but it has the potential to revolutionize medical technology in implantology improving therapies for patients suffering from aseptic endoprosthesis loosening.

In addition, other clinical areas suffering from high inflammation rates might also benefit greatly from the project results.”

Development of market-ready medical products

In coordination with the consortium of European universities and partners in medical device and biotechnology industries, the Fraunhofer IPT will focus on building a market leading portfolio of products, required for application in the next generation of hip revision endoprosthesis and beyond.

In addition to companies using the newly developed EVPRO technology directly, the partners are already working on concepts for sales and distribution along the entire value chain. EVPRO considers process steps of the manufacturing of implants as well as preclinical studies and later end users.

As soon as the EVPRO-implants are market-ready, the partners intend to evaluate the possibility of a comparatively simple transfer from EVPRO hip implant coatings to primary and secondary knee implants, which bear a market potential of more than 3.2 million in the EU and the US per year. As a logical extension for a later stage utilization analysis, further joint replacements such as shoulder, ankle or elbow replacements could also directly benefit from the EVPRO technology.

Additionally, clinical areas connected with high inflammation rates for further EV-loaded products such as intramedullary nails or dental implants, connectors like screws or nails, and wound dressings for chronic wounds or serious burns represent a promising and broad chance for further exploitation of the EVPRO technology.

Partners in the EVPRO consortium

- University Hospital Essen, Essen, Germany, (Bernd Giebel, Verena Börger)
- Lonza Netherlands B.V., Maastricht, the Netherlands, (Bart van Dijk, Birgit Nelsen-Salz)
- Dublin City University, Dublin, Ireland, (Damien King, Paul Cahill)
- Trinity College Dublin, Dublin, Ireland, (Lorraine O´Discroll)
- Leibniz Institute for interactive materials, Aachen, Germany, (Barbara Dittrich, Cesar Rodriguez-Emmenegger)
- University Maastricht, Maastricht, the Netherlands, (Daniel Molin, Nynke van den Akker)
- Meotec GmbH & Co. KG, Aachen, Germany, (Christoph Ptock)
- Stryker B.V., Amsterdam, the Netherlands, (Eric Garling)
- Politecnico di Torino, Turin, Italy, (Gianluca Ciardelli, Valeria Chiono)
- Knappschaftskrankenhaus Bochum, Bochum, Germany, (Jochen Salber)

The EVPRO project started in January 2019 and is funded by the European Union within the Horizon 2020 programme with a total of 5.8 million euros.

Wissenschaftliche Ansprechpartner:

Dr. rer. nat. Claudia Skazik-Voogt

Fraunhofer Institute for Production Technology IPT
Steinbachstr. 17
52074 Germany

Phone +49 241 8904-428

Weitere Informationen:

Susanne Krause, M.A. | Fraunhofer-Institut für Produktionstechnologie IPT

More articles from Medical Engineering:

nachricht Artificial intelligence identifies, locates seizures in real-time
30.06.2020 | Washington University in St. Louis

nachricht Wearable Health
29.06.2020 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electrons in the fast lane

Solar cells based on perovskite compounds could soon make electricity generation from sunlight even more efficient and cheaper. The laboratory efficiency of these perovskite solar cells already exceeds that of the well-known silicon solar cells. An international team led by Stefan Weber from the Max Planck Institute for Polymer Research (MPI-P) in Mainz has found microscopic structures in perovskite crystals that can guide the charge transport in the solar cell. Clever alignment of these "electron highways" could make perovskite solar cells even more powerful.

Solar cells convert sunlight into electricity. During this process, the electrons of the material inside the cell absorb the energy of the light....

Im Focus: The lightest electromagnetic shielding material in the world

Empa researchers have succeeded in applying aerogels to microelectronics: Aerogels based on cellulose nanofibers can effectively shield electromagnetic radiation over a wide frequency range – and they are unrivalled in terms of weight.

Electric motors and electronic devices generate electromagnetic fields that sometimes have to be shielded in order not to affect neighboring electronic...

Im Focus: Gentle wall contact – the right scenario for a fusion power plant

Quasi-continuous power exhaust developed as a wall-friendly method on ASDEX Upgrade

A promising operating mode for the plasma of a future power plant has been developed at the ASDEX Upgrade fusion device at Max Planck Institute for Plasma...

Im Focus: ILA Goes Digital – Automation & Production Technology for Adaptable Aircraft Production

Live event – July 1, 2020 - 11:00 to 11:45 (CET)
"Automation in Aerospace Industry @ Fraunhofer IFAM"

The Fraunhofer Institute for Manufacturing Technology and Advanced Materials IFAM l Stade is presenting its forward-looking R&D portfolio for the first time at...

Im Focus: AI monitoring of laser welding processes - X-ray vision and eavesdropping ensure quality

With an X-ray experiment at the European Synchrotron ESRF in Grenoble (France), Empa researchers were able to demonstrate how well their real-time acoustic monitoring of laser weld seams works. With almost 90 percent reliability, they detected the formation of unwanted pores that impair the quality of weld seams. Thanks to a special evaluation method based on artificial intelligence (AI), the detection process is completed in just 70 milliseconds.

Laser welding is a process suitable for joining metals and thermoplastics. It has become particularly well established in highly automated production, for...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

International conference QuApps shows status quo of quantum technology

02.07.2020 | Event News

Dresden Nexus Conference 2020: Same Time, Virtual Format, Registration Opened

19.05.2020 | Event News

Aachen Machine Tool Colloquium AWK'21 will take place on June 10 and 11, 2021

07.04.2020 | Event News

Latest News

Rising water temperatures could endanger the mating of many fish species

03.07.2020 | Life Sciences

Risk of infection with COVID-19 from singing: First results of aerosol study with the Bavarian Radio Chorus

03.07.2020 | Studies and Analyses

Efficient, Economical and Aesthetic: Researchers Build Electrodes from Leaves

03.07.2020 | Power and Electrical Engineering

Science & Research
Overview of more VideoLinks >>>