The new diagnostic device is effectively a miniature conventional laboratory inside a chip (Lab on a Chip). Moreover, it is highly specific, rapid, portable and user-friendly.
In this way, an ample range of possible users -hospitals, health centres and the food industry, amongst others – have available a device equipped with an optical reading system (fluorescence signal emitted during Polymerase Chain Reaction (PCR) reaction in real time), that enables the rapid identification of pathogens. Within the Chip the system integrates the concentrating of the sample, the rupture of its membrane, the enzymatic multiplication of its DNA and finally identification of the pathogen. The user only has to insert two syringes into the device and the analysis is undertaken automatically.
This research is within the remit of the European OPTOLABCARD project, launched in September 2005 and now about to finish. The project is led by Ikerlan-IK4 and financed by the VI Framework Programme, with an overall budget of 2.9 million euros, and involving the participation of a total of 9 different bodies – DTU-Nano, the Hospital de Donosti through the BIOEF Foundation and Gaiker-IK4 itself, amongst them – and from 6 different countries (Germany, Austria, Denmark, Spain, Poland and Sweden).
Gaiker-IK4’s participation in the project has focused on the adaptation of biochemical developments to the microfluid system of the chip, as well as the optimisation and characterisation of the device for its clinical application and its diagnosis for the presence of Salmonella spp. in persons with colitis. Ikerlan-IK4 has also worked on the development of manufacturing technology for the production of the Laboratory on a Chip. This advance will enable the development of a great variety of new devices in the future.
The OPTOLABCARD project is currently in its final stage, having developed and patented exclusive technology for Micromanufacture and Molecular Diagnosis. The convergence of these two technologies together with the biological results mentioned corroborate the healthy position of IK4 Technological Alliance and is a great opportunity for the development of various and future laboratories miniaturised on a Chip.Applications of the new device
One of the great advantages of this device is the rapidity of the whole process of analysis, including the concentrating and preparation of the sample and the detection of pathogens by PCR, in comparison to the procedures habitually employed in laboratories of reference. Likewise, the device’s easy-to-use handling and portability will enable a diagnostic analysis in the doctor’s surgery itself.
Oihane Lakar Iraizoz | alfa
Further reports about: > DNA > IK4 Technological Alliance > Ikerlan-IK4 > Micromanufacture > Molecular Diagnosis > OPTOLABCARD project > Salmonella > enzymatic multiplication > identification of pathogens > lab on a chip > microfluid system > miniature conventional laboratory > optical reading system > rapid diagnostic device
21.02.2020 | Technical University of Munich (TUM)
Hybrid microscope could bring digital biopsy to the clinic
13.02.2020 | University of Illinois at Urbana-Champaign, News Bureau
The operational speed of semiconductors in various electronic and optoelectronic devices is limited to several gigahertz (a billion oscillations per second). This constrains the upper limit of the operational speed of computing. Now researchers from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg, Germany, and the Indian Institute of Technology in Bombay have explained how these processes can be sped up through the use of light waves and defected solid materials.
Light waves perform several hundred trillion oscillations per second. Hence, it is natural to envision employing light oscillations to drive the electronic...
Most natural and artificial surfaces are rough: metals and even glasses that appear smooth to the naked eye can look like jagged mountain ranges under the microscope. There is currently no uniform theory about the origin of this roughness despite it being observed on all scales, from the atomic to the tectonic. Scientists suspect that the rough surface is formed by irreversible plastic deformation that occurs in many processes of mechanical machining of components such as milling.
Prof. Dr. Lars Pastewka from the Simulation group at the Department of Microsystems Engineering at the University of Freiburg and his team have simulated such...
Investigation of the temperature dependence of the skyrmion Hall effect reveals further insights into possible new data storage devices
The joint research project of Johannes Gutenberg University Mainz (JGU) and the Massachusetts Institute of Technology (MIT) that had previously demonstrated...
Researchers at Chalmers University of Technology, Sweden, recently completed a 5-year research project looking at how to make fibre optic communications systems more energy efficient. Among their proposals are smart, error-correcting data chip circuits, which they refined to be 10 times less energy consumptive. The project has yielded several scientific articles, in publications including Nature Communications.
Streaming films and music, scrolling through social media, and using cloud-based storage services are everyday activities now.
After helping develop a new approach for organic synthesis -- carbon-hydrogen functionalization -- scientists at Emory University are now showing how this approach may apply to drug discovery. Nature Catalysis published their most recent work -- a streamlined process for making a three-dimensional scaffold of keen interest to the pharmaceutical industry.
"Our tools open up whole new chemical space for potential drug targets," says Huw Davies, Emory professor of organic chemistry and senior author of the paper.
12.02.2020 | Event News
16.01.2020 | Event News
15.01.2020 | Event News
21.02.2020 | Medical Engineering
21.02.2020 | Health and Medicine
21.02.2020 | Physics and Astronomy