Researchers from The Children's Hospital of Philadelphia, in a study in the August issue of Pediatrics, reported on neuropsychological effects after surgery for acyanotic heart defects. Acyanotic heart defects, which include abnormal heart valves or a hole between the heart's chambers, are milder and less complex than heart defects which require surgery during infancy.
"Most previous studies of the neurocognitive effects of CPB for pediatric heart surgery have focused on surgery during infancy for complex congenital heart disease," said Michael Quartermain, M.D., pediatric cardiologist and primary investigator of the study. "Those children often have multiple risk factors for cognitive decline, such as genetic syndromes, abnormal brain development and the need for multiple operations. We decided to minimize those confounding factors by focusing on a group of asymptomatic older children with isolated heart disease, and the results are encouraging."
In a prospective study of children aged 5 to 18 years undergoing repair of less complex congenital heart disease, the researchers compared 35 children undergoing open-heart surgery with 19 non-cardiac surgical patients and 12 non-surgical control patients. The researchers administered an in-depth neurospsychological battery of tests including assessment of intelligence, memory, motor skills, attention, and behavior to all children in the study both before and six months after surgery. The researchers reported no significant differences between the bypass and non-bypass groups, with improvements in post-operative cognitive testing seen across the board.
"Cardiopulmonary bypass has long been implicated as a causative factor in abnormal neurocognitive outcomes after cardiac surgery, said Dr. Quartermain. "However, in this study which controlled for the non-bypass effects of open-heart surgery, there was no significant decrease in neuropsychological status in these children and adolescents six months after surgery."
He added that larger, multicenter and longer-term studies should further investigate this question, but that based on the current results, physicians who refer children and adolescents for surgical repair of acyanotic heart defects can be comfortable reassuring families of these findings regarding potential neuropsychological side effects of open-heart surgery.
The Children's Hospital of Philadelphia recently launched a unique multidisciplinary, long-term follow-up program to assess congenital heart patients for neurodevelopmental complications, learning disabilities and behavioral concerns, such as ADHD. In the NeuroCardiac Care Program, children and their families are evaluated by a pediatric cardiologist, pediatric neurologist, developmental pediatrician, occupational and physical therapists, a speech and language pathologist, a dietician and social worker – all during one outpatient visit.
Dr. Quartermain's co-authors were Thomas B. Flynn, Ph.D., J. William Gaynor, M.D., Xuemei Zhang, M.S., Daniel J. Licht, M.D., Rebecca N. Ichord, M.D., Michael L. Nance, M.D., and Gil Wernovsky, M.D., all from The Children's Hospital of Philadelphia, and Richard F .Ittenbach, Ph.D., from Cincinnati Children's Medical Center.
About The Children's Hospital of Philadelphia: The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country, ranking third in National Institutes of Health funding. In addition, its unique family-centered care and public service programs have brought the 460-bed hospital recognition as a leading advocate for children and adolescents. For more information, visit http://www.chop.edu.
Joey McCool Ryan | EurekAlert!
Can radar replace stethoscopes?
14.08.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Novel PET imaging method could track and guide therapy for type 1 diabetes
03.08.2018 | Society of Nuclear Medicine and Molecular Imaging
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
16.08.2018 | Life Sciences
16.08.2018 | Earth Sciences
16.08.2018 | Life Sciences