Genetic health risks in children of assisted reproductive technology
More than three million children have been born as a result of assisted reproductive technologies since the birth of the first “test tube baby” in 1978. While the majority of these children are healthy and normal, as a group they are at greater risk of certain kinds of birth defects and being low birth weight, which is associated with obesity, hypertension and type 2 diabetes later in life.
Carmen Sapienza, a geneticist at Temple University School of Medicine, studies the impact of the environment on genes by comparing one type of chromosome modification, called “DNA methylation” between children conceived in the traditional fashion with children born as a result of assisted reproduction.
“We found that 5-10 percent of these chromosome modifications were different in children born through assisted reproduction, and this altered the expression of nearby genes,” he said. “But we have not yet distinguished whether this is caused by assisted reproductive technologies or other factors such as the couple's infertility.”
Because some of the affected genes are involved in the development of fat tissue and the metabolism of glucose, Sapienza believes it will be important to monitor these children long-term to determine whether they have higher rates of obesity or diabetes.
He notes that even though there were measurable differences in DNA methylation and gene expression between the two groups, only a small fraction of the assisted reproduction children were found to be outside the “normal” range.
Press contact: Preston Moretz, Temple University Communications, 215-204-4380, pmoretz@temple.edu. During the AAAS meeting, contact the researcher directly: Carmen Sapienza, 215- 805-2853, sapienza@temple.edu
Sapienza is a professor of pathology and laboratory medicine and associate director of the Fels Institute for Cancer Research at Temple. His laboratory was among the first to discover DNA methylation differences between maternally and paternally inherited genes. He can be reached during the conference on his cell phone, 215/805-2853
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