A team of researchers have developed a new method to investigate the link between interstitial fluid flow and brain tumors.
Interstitial fluid transports nutrients and removes waste between the organs and tissues in our body. In the brain, interstitial fluid is thought to be composed of circulating cerebrospinal fluid, cellular waste and blood plasma, and past research has shown a link between interstitial fluid flow and an increased invasion rate of glioblastoma, or brain tumor, cells.
A team of biomedical researchers and electrical engineers from the University of Virginia and Virginia Tech recently developed a new method to measure and reconstruct interstitial fluid flow velocities in the brain.
This method gives researchers a first look at interstitial fluid flow dynamics in glioma models, and the technique can readily translate to clinical models already using contrast-enhanced magnetic resonance imaging (MRI). The team describes their method in a special issue focusing on the "Bioengineering of Cancer" in APL Bioengineering, by AIP Publishing.
The team built on an existing dynamic contrast-enhanced MRI technique that's already frequently used in clinics to track tumor growth and movement. "We are excited about our technique because we could potentially translate it to patient data that already exists and look at interstitial fluid motion in those patients," said Jennifer Munson, a lead author on the paper.
Munson touted the team's rigorous validation approach in silico and in vitro. First, the team developed an in vitro model of interstitial fluid flow moving through extracellular space by placing fluid on top of a hydrogel and using MRI to measure how the fluid flowed from top to bottom. Then, they validated their computational model against their experimental measurements.
To further validate their technique, Daniel Abler and Russell Rockne, who are co-authors on the paper, created phantom fluid "flow field," in a computer and then reconstructed that flow using their new imaging methodology. Finally, the team implanted patient-derived glioma cells in mice and examined the mouse tumors using MRI to visualize a real flow field.
The team was surprised to find high variability in the flow's rate and magnitude. "There's been this classical idea that a tumor develops and there's this equivalent flow rate going out in all directions like a sphere," Munson said. "Our method and our visualization approach and modeling show that that's a large oversimplification and we have a very heterogenous system. Sometimes flow is going out, or in, or along the side."
One day, this technique could potentially help researchers predict how a tumor might grow and, therefore, improve cancer treatments. More immediately, the team plans to use their established method "to understand the relationship between the fluid velocities and the growth of the tumors," Munson said.
The article, "MRI analysis to map interstitial flow in the brain tumor microenvironment," is authored by Kathryn M. Kingsmore, Andrea Vaccari, Daniel Abler, Sophia X. Cui, Frederick H. Epstein, Russell C. Rockne, Scott T. Acton and Jennifer M. Munson. The article appeared in APL Bioengineering June 26, 2018, (10.1063/1.5023503) and can be accessed at http://aip.
ABOUT THE JOURNAL
APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering. The journal publishes high-impact manuscripts specific to the understanding and advancement of physics and engineering of biological systems. APL Bioengineering is the new home for the bioengineering and biomedical research communities. See https:/
Julia Majors | EurekAlert!
Artificial intelligence can speed up the detection of stroke
31.03.2020 | University of Turku
Thermopiles for non-contact temperature measurement at humans
31.03.2020 | CiS Forschungsinstitut für Mikrosensorik GmbH
An international team with the participation of Prof. Dr. Michael Kues from the Cluster of Excellence PhoenixD at Leibniz University Hannover has developed a new method for generating quantum-entangled photons in a spectral range of light that was previously inaccessible. The discovery can make the encryption of satellite-based communications much more secure in the future.
A 15-member research team from the UK, Germany and Japan has developed a new method for generating and detecting quantum-entangled photons at a wavelength of...
Together with their colleagues from the University of Würzburg, physicists from the group of Professor Alexander Szameit at the University of Rostock have devised a “funnel” for photons. Their discovery was recently published in the renowned journal Science and holds great promise for novel ultra-sensitive detectors as well as innovative applications in telecommunications and information processing.
The quantum-optical properties of light and its interaction with matter has fascinated the Rostock professor Alexander Szameit since College.
Researchers at the University of Zurich show that different stem cell populations are innervated in distinct ways. Innervation may therefore be crucial for proper tissue regeneration. They also demonstrate that cancer stem cells likewise establish contacts with nerves. Targeting tumour innervation could thus lead to new cancer therapies.
Stem cells can generate a variety of specific tissues and are increasingly used for clinical applications such as the replacement of bone or cartilage....
An international research team led by Kiel University develops an extremely porous material made of "white graphene" for new laser light applications
With a porosity of 99.99 %, it consists practically only of air, making it one of the lightest materials in the world: Aerobornitride is the name of the...
Researchers at Graz University of Technology have developed a framework by which wireless devices with different radio technologies will be able to communicate directly with each other.
Whether networked vehicles that warn of traffic jams in real time, household appliances that can be operated remotely, "wearables" that monitor physical...
26.03.2020 | Event News
23.03.2020 | Event News
03.03.2020 | Event News
31.03.2020 | Life Sciences
31.03.2020 | Life Sciences
31.03.2020 | Medical Engineering