Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

3D-printed Splint Saves Infant’s Life

11.07.2013
Half a millennium after Johannes Gutenberg printed the bible, researchers printed a 3D splint that saved the life of an infant born with severe tracheobronchomalacia, a birth defect that causes the airway to collapse.

While similar surgeries have been preformed using tissue donations and windpipes created from stem cells, this is the first time 3D printing has been used to treat tracheobronchomalacia—at least in a human.

Matthew Wheeler, a University of Illinois Professor of Animal Sciences and member of the Regenerative Biology and Tissue Engineering research theme at the Institute for Genomic Biology (IGB), worked with a team of five researchers to test 3D-printed, bioresorbable airway splints in porcine, or pig, animal models with severe, life-threatening tracheobronchomalacia.

“If the promise of tissue engineering is going to be realized, our translational research must be ‘translated’ from our laboratory and experimental surgery suite to the hospital and clinic,” Wheeler said. “The large-animal model is the roadway to take this device from the bench top to the bedside.”

For more than 40 years, pigs have served as medical research models because their physiology is very similar to humans. In addition to tracheobronchomalacia, pigs have been biomedical models for muscular dystrophy, diabetes, and other diseases. The team chose to use two-month-old pigs for this study because their tracheas have similar biomechanical and anatomical properties to a growing human trachea.

“Essentially, all our breakthroughs in human clinical medicine have been initially tested or perfected in animal models,” Wheeler said. “Through the use of animal models, scientists and doctors are able to perfect techniques, drugs, and materials without risking human lives.”

First, Wheeler sent a CT scan of a pig’s trachea to Scott Hollister, a professor of biomedical engineering at the University of Michigan. Hollister used the CT scan and a 3D CAD program to design and print the splints. These devices were made from an FDA-approved material called polycaprolactone or PCL, which Wheeler has used in more than 100 large-animal procedures.

Next, Wheeler developed a strategy to implement the device and U-M associate professor of pediatric otolaryngology Glenn Green carried out the surgical procedure. After the splint was placed, the pigs’ tracheobronchomalacia symptoms disappeared.

“All of our work is physician inspired,” Wheeler said. “Babies suffering from tracheobronchomalacia were brought to ear, nose and throat surgeons, but they didn’t have any treatment options. They turned to us to engineer a cure.”

Kaiba (KEYE'-buh) Gionfriddo was six weeks old when he suddenly stopped breathing and turned blue at a restaurant with his parents. As a result of severe tracheobronchomalacia, his heart would often stop beating, and despite the aid of a mechanical ventilator, he had to be resuscitated daily by doctors.

April and Bryan Gionfriddo believed their son’s chance of survival was slim until Marc Nelson, a doctor at Akron Children’s Hospital in Ohio, mentioned researchers from the University of Michigan were testing airway splints similar to those used in Wheeler’s study.

After obtaining emergency clearance from the Food and Drug Administration, Hollister and Green used computer-guided lasers to print, stack, and fuse thin layers of plastic to make up Kaiba’s splint.

The splint was sewn around Kaiba’s airway to expand his collapsed bronchus and provide support for tissue growth. A slit in the side of the splint allows it to expand as Kaiba’s airway grows. In about three years, after Kaiba’s trachea has reconstructed itself, his body will reabsorb the splint as the PCL degrades.

Soon Kaiba’s tracheotomy tube will be removed after a year without any breathing crises. His success story provides hope for other children born with this disorder, an estimated 1 in 2,100 births.

“It’s not very rare,” Wheeler said. “It’s really not. I think it’s very rewarding to all of us to know that we are contributing to helping treat or even cure this disease.”

More data from Wheeler’s large animal trials will be essential to show the long-term viability of this procedure before it can be used to save the lives of other children born with this disorder. In future trials, Wheeler plans to add stem cells to the splint in order to accelerate healing.

This translational research was conducted at the IGB, a research facility at the U of I that promotes multi-disciplinary collaboration. The institute is considered by many to be the Midwest region’s center for large-animal biomedical models.

“We have a reputation for being excellent in this area,” Wheeler said. “We would like to capitalize on the expertise and the facilities that we have here to continue to conduct life-saving research. I'm hoping that this story will encourage more people come to us and say 'Hey, we'd like to develop this model.'”

Nicholas Vasi | EurekAlert!
Further information:
http://www.illinois.edu

More articles from Medical Engineering:

nachricht A first look at interstitial fluid flow in the brain
05.07.2018 | American Institute of Physics

nachricht A sentinel to watch over ocular pressure
04.07.2018 | Fraunhofer Institute for Microelectronic Circuits and Systems

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Machine-learning predicted a superhard and high-energy-density tungsten nitride

18.07.2018 | Materials Sciences

NYSCF researchers develop novel bioengineering technique for personalized bone grafts

18.07.2018 | Life Sciences

Why might reading make myopic?

18.07.2018 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>