Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Can the Zebrafish Help US to Search for New Pain Drugs?

04.09.2013
Neuropathic pain is caused by injury of the central or peripheral nervous system. Neuropathic pain is difficult to treat because rarely responds to opiates.

Studying neuropathic pain in humans has major ethical and experimental limitations. The use of alternate mammalian animal models has been the solution for many years. For both human and animal studies scientists had to rely frequently on behavioral tests that may not directly reflect the experience the animal is going through.

Thus, this may be one of the reasons because our ability to treat pain symptoms still relies on a small number of drugs. This suggests that the use of other model systems may help to discovery new compounds with potential analgesic activity.

A new published study in Journal of Cellular Physiology by a team led by Dr. Antonio Giordano and Dr. Gianfranco Bellipanni of Sbarro Institute for Cancer Research and Molecular Medicine and Temple University (Philadelphia, USA) adds a new prospective on the research on pain perception. They used larvae of the small vertebrate zebrafish to show that at the molecular level they respond to stimuli that induce inflammation and axons degenerations similarly to mammals.

“We found the highest temperature zebrafish larvae could survive and exposed them for only 5 seconds, the results where similar to human severe skin burns. “ Dr. Giordano said. “ Then we went to see if the panel of genes, activated by pain in humans, was activated also in the fish. Interestingly, they were activated at the right place and time”.

We asked Dr. Gianfranco Bellipanni to explain how this research could have implications for humans: “to understand better the mechanism of neuropathic pain and to discovery new drugs first we need an animal model that is easy and economic to keep, that shows a high degree of similarity in pain perception and response with mammals and is especially able to offer many technical tools for conducting studies.

Zebrafish matches all these characteristics” he said. “ Now we are creating transgenic zebrafish that became fluorescent in response to painful stimulations. These transgenic fish can be used for in vivo studies. At first we will use these transgenic fish to characterize better the cellular and molecular mechanisms of pain, but our final goal, if we will find the appropriate funding, is to use them for screening for chemicals with potential analgesic activity”.

Other authors of the study include Dr. Valentina Malafoglia and William Raffaeli both at ISAL-Foundation, Institute for Research on Pain, Dr. Marco Colasanti at University of Roma3 and Dr. Darius Balciunas at Temple University.

Dr. Antonio Giordano is Director and Founder of Sbarro Health Research Organization at Philadelphia, PA (www.shro.org) and Professor of Pathology and Oncology at University of Siena, Italy.

Barbara Colombo | Newswise
Further information:
http://www.shro.org

More articles from Life Sciences:

nachricht Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

nachricht Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

NASA keeps watch over space explosions

16.11.2018 | Physics and Astronomy

UNH scientists help provide first-ever views of elusive energy explosion

16.11.2018 | Physics and Astronomy

How the gut ‘talks’ to brown fat

16.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>