Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

WHO handrub formulations are effective against emerging viruses

13.02.2017

In the last few years, previously unknown viruses or viruses, which were considered eliminated, have been unveiled. Antiseptic handrubs are one of the most important measures to limit the pathogen transmission. Since years, the WHO has been providing two antiseptic handrub formulations based on simple materials that could be self-mixed. Scientists at TWINCORE have now demonstrated that these WHO handrub formulations are effectively acting as disinfectants against the well-known infectious agents as well as those emerging and re-emerging viruses.

Last year, the World Health Organization WHO declared “A Public Health Emergency of International Concern” associated with the outbreak of Zika virus. In 2014 and 2015, according to a report by the Robert Koch Institute, 11,000 people in West Africa died of Ebola. In 2012 the MERS virus was detected for the first time – after the SARS epidemic in 2003, a further coronavirus, which triggers a respiratory syndrome.


WHO handrub formulations

Disinfectants are indispensable to reduce the potential risk of infection among the volunteers, medical staffs and people who are living in crisis zones. Antiseptic handrubs are one of the most important measures to limit the pathogen transmission. Since years, the WHO has been providing two antiseptic handrub formulations based on simple materials that could be self-mixed.

The sum of all material for each formulation, the ethanol based formulation I or the isopropanol based formulation II, cost only one tenth of the price of the branded product. Scientists at TWINCORE have now demonstrated that these WHO handrub formulations are effectively acting as disinfectants against the well-known infectious agents as well as those emerging and re-emerging viruses.

“The effect of both antiseptic formulations was never verified against Ebola virus, Zika virus and Coronaviruses. The WHO also consciously has not issued a recommendation for the application of these handrub formulations against those viruses”, says Prof. Eike Steinmann, head of the Research Group Virus Transmission at the Institute for Experimental Virology.

“However, a huge amount of those handrub formulations are in use and we wanted to confirm, whether those formulations could protect the people in crisis zones.” “We” is an international consortium which was coordinated by Eike Steinmann, as the investigated viruses were studied in selected laboratories of the highest safety level in Germany, Switzerland and South Korea.

This comparative study with international partners has now shown that the WHO developed handrub formulations also protect against these new viruses. The air-borne SARS and MERS viruses as well as the vector-transmitted Zika virus are the most labile ones against the WHO antiseptics. The stability of Ebola virus is moderate. "We have also included the vaccinia virus, as it is used as a test virus for the determination of the disinfectant efficacy against enveloped viruses," says Eike Steinmann.

The vaccinia virus is notably stable – if an antiseptic handrub is proved to be potent against this virus, it is also effective against all other well-known enveloped viruses. The study also confirms it as a reference virus when considering the emerging viruses tested in the study. "Even though the results were almost to be expected – knowing that Ebola virus could really be inactivated by both WHO formulations, is important as a fundament for their application in crisis zones”, concludes Eike Steinmann.

Publication: Siddharta et al., Virucidal activity of WHO-recommended formulations against enveloped viruses including Zika, Ebola and emerging Coronaviruses. J Infect Dis. 2017 doi: 10.1093/infdis/jix046. [Epub ahead of print]

Weitere Informationen:

http://www.twincore.de/en/infothek-and-press/infothek-news-single/news/who-handr...

Dr. Jo Schilling |

More articles from Life Sciences:

nachricht Catalysts for climate protection
19.08.2019 | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB

nachricht From the tiny testes of flies, new insight into how genes arise
19.08.2019 | Rockefeller University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A miniature stretchable pump for the next generation of soft robots

Soft robots have a distinct advantage over their rigid forebears: they can adapt to complex environments, handle fragile objects and interact safely with humans. Made from silicone, rubber or other stretchable polymers, they are ideal for use in rehabilitation exoskeletons and robotic clothing. Soft bio-inspired robots could one day be deployed to explore remote or dangerous environments.

Most soft robots are actuated by rigid, noisy pumps that push fluids into the machines' moving parts. Because they are connected to these bulky pumps by tubes,...

Im Focus: Vehicle Emissions: New sensor technology to improve air quality in cities

Researchers at TU Graz are working together with European partners on new possibilities of measuring vehicle emissions.

Today, air pollution is one of the biggest challenges facing European cities. As part of the Horizon 2020 research project CARES (City Air Remote Emission...

Im Focus: Self healing robots that "feel pain"

Over the next three years, researchers from the Vrije Universiteit Brussel, University of Cambridge, École Supérieure de Physique et de Chimie Industrielles de la ville de Paris (ESPCI-Paris) and Empa will be working together with the Dutch Polymer manufacturer SupraPolix on the next generation of robots: (soft) robots that ‘feel pain’ and heal themselves. The partners can count on 3 million Euro in support from the European Commission.

Soon robots will not only be found in factories and laboratories, but will be assisting us in our immediate environment. They will help us in the household, to...

Im Focus: Scientists create the world's thinnest gold

Scientists at the University of Leeds have created a new form of gold which is just two atoms thick - the thinnest unsupported gold ever created.

The researchers measured the thickness of the gold to be 0.47 nanometres - that is one million times thinner than a human finger nail. The material is regarded...

Im Focus: Study on attosecond timescale casts new light on electron dynamics in transition metals

An international team of scientists involving the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) in Hamburg has unraveled the light-induced electron-localization dynamics in transition metals at the attosecond timescale. The team investigated for the first time the many-body electron dynamics in transition metals before thermalization sets in. Their work has now appeared in Nature Physics.

The researchers from ETH Zurich (Switzerland), the MPSD (Germany), the Center for Computational Sciences of University of Tsukuba (Japan) and the Center for...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

The power of thought – the key to success: CYBATHLON BCI Series 2019

16.08.2019 | Event News

4th Hybrid Materials and Structures 2020 28 - 29 April 2020, Karlsruhe, Germany

14.08.2019 | Event News

What will the digital city of the future look like? City Science Summit on 1st and 2nd October 2019 in Hamburg

12.08.2019 | Event News

 
Latest News

Stanford builds a heat shield just 10 atoms thick to protect electronic devices

19.08.2019 | Information Technology

Researchers demonstrate three-dimensional quantum hall effect for the first time

19.08.2019 | Physics and Astronomy

Catalysts for climate protection

19.08.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>