The project is motivated by VTT's discovery of early metabolic signatures predictive of later progression to autoimmunity and type 1 diabetes. These metabolic signatures suggest the potential role of gut microbiota in early T1D pathogenesis.
Therefore, in this project the aim is to discover specific microbes or lack of them associated with later progression to T1D, and to utilize that information for developing new prevention strategies. If the tests for the prevention strategies are successful the intervention can be considered for clinical stages.
The project is initiated and coordinated by Prof. Matej Orešiè from VTT. It combines expertise in systems biology and metabolomics (VTT), clinical type 1 diabetes research (Prof. Olli Simell and his group from the Turku University Hospital and the Finnish Type 1 Diabetes Prediction and Prevention Study DIPP), and microbiology (Prof. Fredrik Bäckhed, University of Gothenburg).
The project “The gut microbiota as a novel target for prevention of type 1 diabetes” is coordinated by VTT and it is funded by the Juvenile Diabetes Research Foundation in USA.
It has been recently reported (Harjutsalo V, Sjöberg L, Tuomilehto J. Lancet. 2008;371: 1777-82) that based on current trends the incidence of type 1 diabetes in Finland will double within next 15 years and the age of onset will be younger (0-4 years). T1D is and will be therefore a major healthcare issue in Finland, and increasingly also in other Western countries. Discovery of preventive therapies capable of preventing or delaying the onset of type 1 diabetes would thus have major implications for healthcare.
Professor Matej Orešiè | VTT
Colorectal cancer risk factors decrypted
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Algae Have Land Genes
13.07.2018 | Julius-Maximilians-Universität Würzburg
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
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Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
13.07.2018 | Event News
13.07.2018 | Materials Sciences
13.07.2018 | Life Sciences