Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Vitamin A in cattle fodder is potentially protecting against cow's milk allergy

06.02.2018

Infants can sometimes develop an allergy to cow's milk that usually subsides by adulthood but may increase the risk for developing other allergic diseases. The allergic reaction can, however, be prevented by two components of cow's milk interacting together, as researchers of the interuniversity Messerli Research Institute of Vetmeduni Vienna, Meduni Vienna und the University of Vienna now describe in a study published in Scientific Reports. Loading of the vitamin A metabolite retinoic acid to the important milk protein Bos d 5, also known as beta-lactoglobulin, in cow’s milk can prevent an allergic reaction against the protein.

A real milk allergy occurs in about three to five percent of European children and more rarely in adults. The disease is different from lactose intolerance, in which a lack of the enzyme lactase results in the inability to properly break down lactose, a sugar found in milk products. In the case of a milk allergy, the immune system itself reacts with a distinct immune response against the milk proteins. Specialized immune cells are formed which produce antibodies against the milk proteins and so trigger a potentially much more dangerous allergic reaction.


Cattle fodder enriched with vitamin A can prevent an allergic reaction against milk Proteins.

Georg Mair/Vetmeduni Vienna

A study of the interuniversity Messerli Research Institute of Vetmeduni Vienna, Meduni Vienna and the University of Vienna has now shown that the components of the cow's milk itself can help to prevent this reaction. The key is that the milk protein beta-lactoglobulin, a relevant agent for allergic reactions, literally "pockets" a metabolite of vitamin A called retinoic acid. This, however, would require cows to receive a sufficient supply of this vitamin, for example, through an abundance of green fodder.

Loading with retinoic acid transforms a potential milk allergen into a milk tolerogen

If infants become allergic to cow's milk, their bodies produce so-called Th2 lymphocytes. These are specialized immune cells that produce antibodies to fight milk proteins as part of the immune system. One of the most important of these so-called milk allergens is the protein Bos d 5. Also known as beta-lactoglobulin, it is part of a family of proteins known as the lipocalins. "This special protein family is characterized by molecular pockets that can take in small molecules like retinoic acid, which is a metabolite of vitamin A," explains first author Karin Hufnagl.

"Our study showed that an 'empty' milk protein supports the activation of Th2 lymphocytes and so initiates an allergic chain reaction," says Hufnagl. However, if it, so to speak, pockets the retinoic acid, then the immune cells react moderately, without an allergic immune reaction. "An adequate loading of the milk protein could thus prevent that small children or even adults become sensitized and express a milk allergy," summarizes study leader Erika Jensen-Jarolim.

No artificial supplements: vitamin-A-enriched fodder during milk production is the key

Milk, and above all cow's milk, is an essential food product for most people. For allergy patients, however, it poses a risk. Besides causing a swelling of the mouth or the mucous membranes, other symptoms can include diarrhoea or aggravated atopic dermatitis, and, in rare cases, can even induce an allergic shock. In addition, a cow's milk allergy carries the risk of other allergic diseases, such as atopic dermatitis or allergic asthma.

"A sufficient supply of vitamin A to the milk producers, i.e. the cows, could counteract this effect in which a harmless food protein is converted into a milk allergen," says Hufnagl. It is uncertain, however, whether the positive effect of natural vitamin A shown in the study can also be achieved through dietary supplements.

"Artificial supplementation of a diet with vitamins may not achieve the same effect as natural agents and will likely result in inadequate loading of the milk allergen. It is therefore necessary to supply vitamin A to an appropriate extent already during the keeping or feeding of the animals. This can be achieved, for example, by increasing the supply of green fodder. Corresponding follow-up studies must still be carried out, however," says Hufnagl.

Service:
The article “Retinoic acid prevents immunogenicity of milk lipocalin Bos d 5 through binding to its immunodominant T-cell epitope“ by Hufnagl K., Ghosh D., Wagner S., Fiocchi A., Dada L., Bianchini R., Braun N., Steinborn R., Hofer M., Blaschitz M., Roth G., Hofstetter G., Roth-Walter F., Pacios LF. and Jensen-Jarolim E. was published in Scientific Reports.
https://www.nature.com/articles/s41598-018-19883-0

About the University of Veterinary Medicine, Vienna
The University of Veterinary Medicine, Vienna in Austria is one of the leading academic and research institutions in the field of Veterinary Sciences in Europe. About 1,300 employees and 2,300 students work on the campus in the north of Vienna which also houses five university clinics and various research sites. Outside of Vienna the university operates Teaching and Research Farms. The Vetmeduni Vienna plays in the global top league: in 2017, it occupies the excellent place 8 in the world-wide Shanghai University veterinary in the subject "Veterinary Science". http://www.vetmeduni.ac.at

About Messerli Research Institute
The Messerli Research Institute was founded in 2010 with support from the Messerli Foundation (Sörenberg, Switzerland) under the management of the University of Veterinary Medicine, Vienna in cooperation with the Medical University of Vienna and the University of Vienna. The research is devoted to the interaction between humans and animals, as well as its theoretical principles in animal cognition and behavior, comparative medicine and ethics. Its work is characterized by its broad interdisciplinary approach (biology, human medicine, veterinary medicine, philosophy, psychology, law) and strong international focus. http://www.vetmeduni.ac.at/en/messerli/

Scientific Contact:
Karin Hufnagl
Comparative Medicine
Messerli Research Institute
University of Veterinary Medicine Vienna (Vetmeduni Vienna)
T +43 664 602572668
karin.hufnagl@vetmeduni.ac.at

Released by:
Georg Mair
Science Communication / Corporate Communications
University of Veterinary Medicine Vienna (Vetmeduni Vienna)
T +43 1 25077-1165
georg.mair@vetmeduni.ac.at

Weitere Informationen:

http://www.vetmeduni.ac.at/en/infoservice/presseinformation/presse-releases-2018...

Mag.rer.nat. Georg Mair | idw - Informationsdienst Wissenschaft

Further reports about: Veterinary Medicine acid immune cells milk protein retinoic acid vitamin A

More articles from Life Sciences:

nachricht Residues in fingerprints hold clues to their age
23.01.2020 | American Chemical Society

nachricht Here, there and everywhere: Large and giant viruses abound globally
23.01.2020 | DOE/Lawrence Berkeley National Laboratory

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Integrate Micro Chips for electronic Skin

Researchers from Dresden and Osaka present the first fully integrated flexible electronics made of magnetic sensors and organic circuits which opens the path towards the development of electronic skin.

Human skin is a fascinating and multifunctional organ with unique properties originating from its flexible and compliant nature. It allows for interfacing with...

Im Focus: Dresden researchers discover resistance mechanism in aggressive cancer

Protease blocks guardian function against uncontrolled cell division

Researchers of the Carl Gustav Carus University Hospital Dresden at the National Center for Tumor Diseases Dresden (NCT/UCC), together with an international...

Im Focus: New roles found for Huntington's disease protein

Crucial role in synapse formation could be new avenue toward treatment

A Duke University research team has identified a new function of a gene called huntingtin, a mutation of which underlies the progressive neurodegenerative...

Im Focus: A new look at 'strange metals'

For years, a new synthesis method has been developed at TU Wien (Vienna) to unlock the secrets of "strange metals". Now a breakthrough has been achieved. The results have been published in "Science".

Superconductors allow electrical current to flow without any resistance - but only below a certain critical temperature. Many materials have to be cooled down...

Im Focus: Programmable nests for cells

KIT researchers develop novel composites of DNA, silica particles, and carbon nanotubes -- Properties can be tailored to various applications

Using DNA, smallest silica particles, and carbon nanotubes, researchers of Karlsruhe Institute of Technology (KIT) developed novel programmable materials....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

„Advanced Battery Power“- Conference, Contributions are welcome!

07.01.2020 | Event News

 
Latest News

Physicists trap light in nanoresonators for record time

23.01.2020 | Physics and Astronomy

The easy route the easy way: New chip calculates the shortest distance in an instant

23.01.2020 | Information Technology

DYNAFLEX® at e-World 2020

23.01.2020 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>