Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Unique jumps in the genome

03.05.2019

Mobile elements or retrotransposons occupy more than half of the human genome – with a complex and multifaceted influence on our existence. On the one hand, they can fortuitously acquire important functions influencing the structure and regulation of our genes. On the other hand, uncontrolled multiple jumps can lead to genetic diseases and mistakes in gene regulation. Liliya Doronina and colleagues from the Medical Faculty of the University of Münster, investigated (i) how frequently do mobile elements independently insert into an identical genomic place in two organisms and (ii) how frequently are established mobile elements exactly excised from their genomic locus.

Mobile elements or retrotransposons occupy more than half of the human genome. Once they were described as genomic parasites, but it is now realised that they have a more complex and multifaceted influence on our existence. On the one hand, they can fortuitously acquire important functions influencing the structure and regulation of our genes.


Dr. Liliya Doronina, PD Dr. Jürgen Schmitz and biology student Olga Reising are excited about the publication of their study.

FZ / Tronquet

On the other hand, uncontrolled multiple jumps can lead to genetic diseases and mistakes in gene regulation and can cause cancer. During evolution, our organism developed a defence system to minimize the activity of mobile elements and their harmful impacts. However, although most of our mobile elements, inherited from our mammalian ancestors, are inactive, some elements retain their activity and up to fifty diseases are known to be caused by retrotransposons.

As a practical by-product, the insertion patterns of mobile elements can serve as markers of the evolutionary relatedness of their carriers. Genomic mobile elements shared by two species indicate a shared ancestry of their carriers, as long as the elements did not jump independently into the same genomic places in the two species or were not removed exactly from either of the genomes, both of which lead to the occurrence of false positive phylogenetic signals, also known as homoplasy (from Greek homos=same; plasis=form).

Therefore, to reliably use these markers, it is essential to know how frequently such independent retrotransposon jumps may hit the same target site in genomes and how often they are exactly deleted.

Liliya Doronina and her colleagues from the group of Jürgen Schmitz in the Medical Faculty of the University of Münster in Germany, investigated exactly these questions: (1) how frequently do mobile elements independently insert into an identical genomic place in two organisms and (2) how frequently are established mobile elements exactly excised from their genomic locus.

They analyzed hundreds of thousands of unique retrotransposon insertions in human and other primate genomes. Only a very few cases of parallel retrotransposon insertions and precise deletions were found, confirming that these events are extremely rare.

Due to their uniqueness and irreversibility, retrotransposon insertion patterns are therefore reliable sources for identifying the evolutionary relatedness among species, even among those with complex evolutionary histories, and are indeed excellent markers to reconstruct evolutionary trees.

The presence of a retrotransposon in the same genomic position in several species does indeed indicate their common origin. Moreover, in light of the new study, the potential risk of recurring mobile element insertion-caused genetic diseases is nearly excluded.

The study is entitled “True Homoplasy of Retrotransposon Insertions in Primates” by Liliya Doronina, Olga Reising, Hiram Clawson, David A. Ray, and Jürgen Schmitz, and is now published in the journal Systematic Biology.

Wissenschaftliche Ansprechpartner:

Dr. Liliya Doronina
University of Münster
Center for Molecular Biology of Inflammation
Von-Esmarch-Straße 56, 48149 Münster
Tel.: 0251 83 52101
Liliya.Doronina@wwu.de

Originalpublikation:

Doronina L. et al. True Homoplasy of Retrotransposon Insertions in Primates. Systematic Biology, Volume 68, Issue 3, May 2019, Pages 482–493, https://doi.org/10.1093/sysbio/syy076

Dr. Thomas Bauer | idw - Informationsdienst Wissenschaft
Further information:
https://www.uni-muenster.de/

More articles from Life Sciences:

nachricht Towards better anti-cancer drugs: New insights into CDK8, an important human oncogene
28.01.2020 | Universität Bayreuth

nachricht Unique centromere type discovered in the European dodder
28.01.2020 | Leibniz Institute of Plant Genetics and Crop Plant Research

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Integrate Micro Chips for electronic Skin

Researchers from Dresden and Osaka present the first fully integrated flexible electronics made of magnetic sensors and organic circuits which opens the path towards the development of electronic skin.

Human skin is a fascinating and multifunctional organ with unique properties originating from its flexible and compliant nature. It allows for interfacing with...

Im Focus: Dresden researchers discover resistance mechanism in aggressive cancer

Protease blocks guardian function against uncontrolled cell division

Researchers of the Carl Gustav Carus University Hospital Dresden at the National Center for Tumor Diseases Dresden (NCT/UCC), together with an international...

Im Focus: New roles found for Huntington's disease protein

Crucial role in synapse formation could be new avenue toward treatment

A Duke University research team has identified a new function of a gene called huntingtin, a mutation of which underlies the progressive neurodegenerative...

Im Focus: A new look at 'strange metals'

For years, a new synthesis method has been developed at TU Wien (Vienna) to unlock the secrets of "strange metals". Now a breakthrough has been achieved. The results have been published in "Science".

Superconductors allow electrical current to flow without any resistance - but only below a certain critical temperature. Many materials have to be cooled down...

Im Focus: Programmable nests for cells

KIT researchers develop novel composites of DNA, silica particles, and carbon nanotubes -- Properties can be tailored to various applications

Using DNA, smallest silica particles, and carbon nanotubes, researchers of Karlsruhe Institute of Technology (KIT) developed novel programmable materials....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

„Advanced Battery Power“- Conference, Contributions are welcome!

07.01.2020 | Event News

 
Latest News

Towards better anti-cancer drugs: New insights into CDK8, an important human oncogene

28.01.2020 | Life Sciences

Rice lab turns trash into valuable graphene in a flash

28.01.2020 | Materials Sciences

AI can jump-start radiation therapy for cancer patients

28.01.2020 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>