Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Unexpected flexibility found in odorant molecules

27.06.2016

High resolution rotational spectroscopy reveals an unprecedented number of conformations of an odorant molecule – a new world record!

In a recent publication in the journal Physical Chemistry Chemical Physics, researchers from the Max Planck Institute for the Structure and Dynamics of Matter at the Center for Free-Electron Laser Science and from the Hamburg Centre for Ultrafast Imaging (CUI) led by Melanie Schnell have unraveled the complex conformational landscape of an odorant biomolecule.


Structure of the most stable globular form of citronellal.

© S. R. Domingos / MPI for the Structure and Dynamics of Matter

The science of the scent is shrouded in mystery. How our body interprets odor is still a subject of active debate worldwide. We do know however, that the functionality of a specific biomolecule is directly related to how the molecule “fits” in its target biological receptor, much like a key that only fits in a certain door lock. Many biochemical processes are governed by this so-called lock-and-key mechanism. The size, shape and flexibility of the key are what defines how good it binds to its target, i.e., can it or can it not open the right door?

To shed some light on these mechanisms, the researchers performed a high-resolution rotational spectroscopy study using citronellal, a versatile biochemical precursor that naturally appears in many plant oils. It has a distinct lemon scent and is often exploited in the cosmetics industry.

The researchers discovered that this molecule can adopt an impressive number of shapes simply by rotation around five single carbon-carbon chemical bonds. Those orchestrated rotations result in an extraordinarily large number of stable forms of the molecule.

A total of fifteen forms have been identified. “We show evidence that this incredibly flexible system has a preference for globular shapes, i.e., it likes to fold on itself,” says Sérgio Domingos, first author of this work. “This observation allowed us to derive important information concerning the possible interactions of this molecule with its biological receptors.”

The number of conformations (keys) observed for this molecule constitutes a world record for the microwave spectroscopy community. “The extraordinary shape-shifting ability of this odorant molecule provides particular insights on the relation between structure and function of a biomolecule. Not only we found fifteen keys, but we also know which ones might fit better in the door lock,” concludes group leader Melanie Schnell.

Contact persons:

Dr. Sérgio Domingos
Max Planck Institute for the Structure and Dynamics of Matter
Center for Free-Electron Laser Science
Luruper Chaussee 149
22761 Hamburg
Germany
+49 (0)40 8998-6233
sergio.domingos@mpsd.mpg.de

PD Dr. Melanie Schnell
Max Planck Institute for the Structure and Dynamics of Matter
Center for Free-Electron Laser Science
Luruper Chaussee 149
22761 Hamburg
Germany
+49 (0)40 8998-6240
melanie.schnell@mpsd.mpg.de

Original publication:

S. R. Domingos, C. Pérez, C. Medcraft, P. Pinacho, and M. Schnell, "Flexibility unleashed in acyclic monoterpenes: conformational space of citronellal revealed by broadband rotational spectroscopy," Physical Chemistry Chemical Physics 18 (25), 16682-16689 (2016); DOI: 10.1039/C6CP02876D

Weitere Informationen:

http://dx.doi.org/10.1039/C6CP02876D Original publication
http://www.mpsd.mpg.de/en/research/irg/ccm Research group of PD Dr. Melanie Schnell
http://www.mpsd.mpg.de/en Max Planck Institute for the Structure and Dynamics of Matter

Dr. Michael Grefe | Max-Planck-Institut für Struktur und Dynamik der Materie

Further reports about: Laser Max-Planck-Institut biomolecule odorant spectroscopy

More articles from Life Sciences:

nachricht NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation

nachricht Pollen taxi for bacteria
18.07.2018 | Technische Universität München

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

NYSCF researchers develop novel bioengineering technique for personalized bone grafts

18.07.2018 | Life Sciences

Machine-learning predicted a superhard and high-energy-density tungsten nitride

18.07.2018 | Materials Sciences

Why might reading make myopic?

18.07.2018 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>