Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Understanding a bacterial immune system 1 step at a time

18.05.2011
Researchers at the University of Alberta have taken an important step in understanding an immune system of bacteria, a finding that could have implications for medical care and both the pharmaceutical and dairy industries.

In research published in the high impact journal Nature Structural & Molecular Biology, Andrew MacMillan and co-workers in his lab have described the first step of the immune response of bacterial cells. Scientists had previously found that a bacterial virus, called a bacteriophage, attacks a bacterial cell by injecting its DNA in to the cell. MacMillan's lab discovered the mechanism by which bacterial RNA is cut into pieces by a specific protein; these pieces then target the invading virus' DNA.

"We are starting at the beginning because we want to understand how this works and how we can use this to basically control bacterial growth," said Matt Schellenberg, a post-doctoral fellow in the MacMillan lab in the department of biochemistry in the Faculty of Medicine & Dentistry. This system could be beneficial for bacteria to fight off invasion of viruses. Alternatively, medical professionals could use knowledge of this system to help fight a human bacterial infection.

According to MacMillan they used a technique called X-ray crystallography to produce high-resolution pictures of a key step in the bacteria's immune response — the production of the targeting RNAs.

... more about:
»DNA »MacMillan »RNA »immune response »immune system

"Bacteria have evolved this system to protect themselves against infection," said MacMillan.

As they unfold the mystery of the bacteria cells immune system, which is named the CRISPR system, there are implications for a variety of industrial practices involving fermentation. Everything from cheese and yogurt production to the synthesis of complex pharmaceuticals relies on large scale bacterial fermentation which is at risk of bacteriophage infection with expensive consequences – losing the batch. The labs ongoing work could help these industries boost the immune systems of the "good" bacteria.

The next step for the lab is to uncover the mechanism by which virus' DNA is destroyed.

"We want to use what we've learned so far to examine the actual targeting mechanism," says Macmillan. "This is a complex pathway and there's a lot of exciting biology to still uncover."

Quinn Phillips | EurekAlert!
Further information:
http://www.ualberta.ca

Further reports about: DNA MacMillan RNA immune response immune system

More articles from Life Sciences:

nachricht Researchers target protein that protects bacteria's DNA 'recipes'
21.08.2018 | University of Rochester

nachricht Protein interaction helps Yersinia cause disease
21.08.2018 | Schwedischer Forschungsrat - The Swedish Research Council

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: It’s All in the Mix: Jülich Researchers are Developing Fast-Charging Solid-State Batteries

There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.

The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Air pollution leads to cardiovascular diseases

21.08.2018 | Ecology, The Environment and Conservation

Researchers target protein that protects bacteria's DNA 'recipes'

21.08.2018 | Life Sciences

A paper battery powered by bacteria

21.08.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>