Helicobacter pylori is a bacterial strain that can infect the human stomach and induce inflammation, ulcers, and potentially even stomach cancer. However, only a small fraction of H. pylori infections ultimately lead to cancer, leading researchers to figure out what biological events will trigger this path.
One type of H. pylori strain that seems to increase disease risk is the cag+ strain, which contains a set of proteins that allows it to inject bacterial proteins into cells following attachment to the stomach lining; this interaction between bacteria and gastric cells may be a key contributor to chronic damage.
Richard Peek and colleagues investigated a cag+ strain in mouse models of H. pylori infection and found that a protein called CagE could induce gastric cells to turn on a receptor called Decay-accelerating factor (DAF); DAF acts to remove nearby immune proteins that can kill cells to prevent unwanted immune damage.
In essence, the bacteria use the DAF receptor on the host cell they're attached to like a bodyguard to protect them from the immune system. Peek and colleagues also note that by continually inducing DAF expression, H. pylori creates an environment of persistent inflammation that can reduce the threshold required for more serious diseases to develop.
From the JBC article: "Regulation of the Helicobacter pylori cellular receptor Decay-accelerating Factor" by Daniel O'Brien, Judith Romero-Gallo, Barbara G. Schneider, Rupesh Chaturvedi, Alberto Delgado, Elizabeth J. Harris, Uma Krishna, Seth R. Ogden, Dawn A. Israel, Keith T. Wilson, and Richard M. Peek Jr
Article Link: http://www.jbc.org/cgi/content/abstract/M801144200v1
Corresponding Author: Richard M. Peek Jr., Division of Gastroenterology, Vanderbilt University School of Medicine, Nashville, TN; Tel: 615-322-5200, Email: Richard.firstname.lastname@example.org
The American Society for Biochemistry and Molecular Biology is a nonprofit scientific and educational organization with over 11,900 members in the United States and internationally. Most members teach and conduct research at colleges and universities. Others conduct research in various government laboratories, nonprofit research institutions and industry. The Society's student members attend undergraduate or graduate institutions.
Founded in 1906, the Society is based in Bethesda, Maryland, on the campus of the Federation of American Societies for Experimental Biology. The Society's purpose is to advance the science of biochemistry and molecular biology through publication of the Journal of Biological Chemistry, the Journal of Lipid Research, and Molecular and Cellular Proteomics, organization of scientific meetings, advocacy for funding of basic research and education, support of science education at all levels, and promoting the diversity of individuals entering the scientific work force.
Nick Zagorski | EurekAlert!
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
16.11.2018 | Health and Medicine
16.11.2018 | Life Sciences
16.11.2018 | Life Sciences